medRxiv
January 4, 2024
Marcelo Falchi-Carvalho, Handersson Barros, Raynara Bolcont et al.
5 citations
preprint
Abstract Introduction N,N-Dimethyltryptamine (DMT), a naturally occurring psychedelic tryptamine contained in the indigenous ayahuasca brew has shown antidepressant effects. This Phase 2a clinical trial investigates for the first time the efficacy of isolated DMT in treatment-resistant depression (TRD). Methods Six TRD patients participated in an open-label, fixed-order, dose-escalation study,...
Journal of Child and Adolescent Psychopharmacology
January 3, 2024
Alice Lineham, Victor J. Avila‐quintero, Michael H. Bloch et al.
15 citations
Objective:Ketamine has proved effective as a rapid-acting antidepressant agent, but treatment is not effective for everyone (approximately a quarter to a half of patients). Some adult studies have begun to investigate predictors of ketamine's antidepressant response, but no studies have examined this in adolescents with depression. Methods:We conducted a secondary data analysis of adolescents...
BMC Psychiatry
January 2, 2024
Minna Chang, Mario F Juruena, Allan H. Young
16 citations
Abstract Background Ketamine is a novel and exciting putative antidepressant medication for patients with treatment-resistant depression. A complication commonly seen in frequent and heavy recreational use of ketamine is ulcerative cystitis, which presents with lower urinary tract symptoms (LUTS) and upper renal tract damage and can be seen in over 25% of regular users. Although...
Clinical Psychology & Psychotherapy
2024
Ali Kandeğer, Şerife Odabaş Ünal, Muhammed Tuğrul Ergün et al.
AbstractBackgroundPersistent mind‐wandering processes are associated with negative emotions; however, mindful states exhibit an anticorrelation with mind‐wandering patterns. The aim of this study is to investigate the mediating role of excessive mind wandering (EMW), rumination, and trait mindfulness between attention‐deficit hyperactivity disorder (ADHD) symptoms and the severity of...
Journal of Assessment and Research in Applied Counseling
2024
Mahdi Chitsaz, Ezzatollah Ahmadi, Hassan Bafandeh Qaramaleki
Objective: The present study aimed to determine the effectiveness of mindfulness-based intervention on sleep problems and depression in adolescents. Methods and Materials: This research was a quasi-experimental study with a pre-test and post-test design, along with a control group. The statistical population included all high school students with sleep problems in the city of Azarshahr during...
Journal of Assessment and Research in Applied Counseling
2024
Elham Ghalandari, Bahram Mirzaian, Seyedeh Olia Emadian
Objective: The aim of the present study was to examine the effectiveness of mindfulness-based cognitive therapy on self-blame and cognitive avoidance in adolescents with subclinical depression. Methods and Materials: This research utilized a quasi-experimental method with a pretest-posttest design and a control group. The statistical population of the present study consisted of all...
Telangana Journal of Psychiatry
2024
Pallavi Preetinanda, Srikrishna Nukala, Abhilash Garapati et al.
Treatment-resistant depression (TRD) is one of the most debilitating conditions that does not respond to conventional pharmacotherapy. Ketamine is a recently used effective treatment option in depressive disorders with a novel mechanism of action. Still, studies estimating the improvement of depressive symptoms in TRD with multiple doses of ketamine are limited. Hence, we report 5 TRD cases...
The Brown University Psychopharmacology Update
2024
A Phase 3b open‐label trial has found that esketamine nasal spray in combination with an antidepressant was more efficacious than extended‐release quetiapine plus an antidepressant in patients with treatment‐resistant depression. Both patient groups experienced improved remission rates over time.
American Journal of Therapeutics
2024
Kristine C. Willett, LeDea R. Bond, Amanda M. Morrill et al.
Background: Major depressive disorder (MDD) affects millions of people and is the leading cause of disability worldwide. Patients report decreased quality of life and ability to perform activities of daily living. It is estimated that the current standard of care, which includes pharmacologic therapy with a selective serotonin reuptake inhibitor, is effective in 40%–60%. Additional treatment...
PLoS One
2024
Karim S Ladha, Jiwon Lee, Gabriella Mattina et al.
Nitrous oxide has shown potentially as an efficacious intervention for treatment-resistant depression, yet there remains insufficient evidence pertaining to repeated administration of nitrous oxide over time and active placebo-controlled studies with optimal blinding. Thus, we aim to examine the feasibility and preliminary efficacy of a six-week follow up study examining the effects of a 4 week...