Investigation of Default Mode Network by very low frequency EEG network analysis
Sho Ageno, Keiji Iramina
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study |
|---|---|
| Topics | Default mode network |
| Key findings | Functional connectivity in the sub-delta band (0.01–0.1 Hz) is higher during eye-closed resting than during mental arithmetic, indicating EEG can detect DMN activity. |
Abstract
One of the resting state networks is the default mode network (DMN); the DMN is primarily concerned with self-perception, orientation, and memory. Although EEG-DMN has been suggested to be active in the ultra-low frequency band below 1 Hz based on fMRI studies, the characteristics of the network have not yet been elucidated. In this study, we measured EEG-DMN during the eye-closed resting state(EC), eye-open resting state(EO), and mental arithmetic with eye-close(CA), and analyzed network activity using phase locking value(PLV), an index of phase-locking, which is one of the functional connectivity. The results showed that functional connectivity between regions (frontal, central, posterior, occipital) including DMN-related regions in SubDelta (0.01-0.1Hz) was significantly higher during eye-closed resting state than during mental arithmetic with eye-close (EC PLV - CA PLV in Frontal-Posterior = 0.062). In contrast, in the high frequency band(Theta), PLV during mental arithmetic with eye-close was significantly higher than during eye-closed resting between Occipital-Right temporal (EC PLV – CA PLV in Posterior-Right temporal = -0.051). This finding is similar to previous studies and suggests that the analysis of functional connectivity in the very low-frequency band below 0.1 Hz can reveal EEG-DMN activity. This result indicates that DMN activity can be captured not only by fMRI and intracranial EEG (iEEG) but also by cortical EEG. This will contribute to the elucidation of the pathology of diseases with reported abnormal DMN activity, such as depression and dementia, as well as to the further elucidation of DMN function.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |