Journal of Pharmacology and Experimental Therapeutics
October 1, 1994
Tissue levels of serotonin (5-HT), levels of its metabolite 5-hydroxyindoleacetic acid (5-HIAA) and populations of 5-HT reuptake sites were measured in the brains of rats exposed to 3,4-methylenedioxymethamphetamine (MDMA) at selected developmental ages. MDMA exposure at postnatal day (PND) 10 did not result in altered 5-HT or 5-HIAA levels 1 week after administration in any brain region...
Neuroscience
September 1994
S R White, P Duffy, P W Kalivas
The nucleus accumbens has been implicated as an important site for the actions of many drugs that are used recreationally. This study examined the effects of methylenedioxymethamphetamine (MDMA), a euphoric and hallucinogenic drug, on glutamate-evoked neuronal firing and on extracellular levels of dopamine and serotonin in the nucleus accumbens of the rat. Microiontophoretic application of MDMA...
Imagination, Cognition and Personality
September 1, 1994
Peter L. Nelson
This article argues that the so-called cannabis “amotivation syndrome,” widely reported in the literature, may not be a single nosological entity, but represent, instead, a change in cognitive style emerging as a result of cannabis's ability to facilitate a unique attentional state favoured by those who have a higher than average level of a personality factor referred to as “trait absorption.”...
The British Journal of Psychiatry
September 1, 1994
Philip Mcguire, Helen Cope, Thomas Fahy
187 citations
Background 3,4-methylenedioxymethamphetamine (MDMA or ‘Ecstasy’) has become one of the most widely used illicit substances in the UK. Little is known of the psychiatric morbidity which may be associated with its use. We have examined this association by collecting a series of psychiatric cases in which MDMA use was a prominent feature. Method Patients presenting between 1990 and 1992 with...
Brain Research
June 13, 1994
P M Lalley
37 citations
5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) is an indolealkylamine which has agonist activity at 5HT receptors. In the present investigation, 5-MeODMT had two types of effects on medullary respiratory neurons of the cat. Iontophoretic administration or i.v. doses (43 +/- 8.9 micrograms/kg) of 5-MeODMT hyperpolarized respiratory neurons and severely reduced action potential discharges....
Perspectives in biology and medicine
March 1, 1994
Erwin Di Cyan
SOME EFFECTS OF GROUP DRUG TAKING ERWIN DI CYAN* The purpose of this paper is to discuss briefly some aspects of the differences between drug effects when drugs are used in groups as distinguished from their solitary use. The human organism responds to a variety of stimuli. Its response to signals may be physiological or psychological. The latter response includes recollections by (a) retrieval...
Journal of Psychopharmacology
1994
Hugh Series, Sietske Boeles, Eluned Dorkins et al.
44 citations
Two case reports are presented of significant psychiatric disorders associated with ingestion of 'Ecstasy' (3,4-methylenedioxymethamphetamine), a recreational drug whose use appears to be increasing. In one case, the patient developed a brief paranoid psychosis which recurred and persisted for at least a month after he took a second dose of the drug. In the other, the patient experienced...
Acta Psychiatrica Scandinavica
December 1, 1993
E H Kua, P H Chew, S M Ko
48 citations
This is a study of the illness behaviour of 100 Chinese psychiatric patients referred consecutively to the psychiatric unit of a general hospital in Singapore. More women than men felt that their illness was due to spirit possession; but belief in possession was not related to educational status. Thirty-six patients or their relatives had consulted a traditional healer before going to the...
Pharmacology, Biochemistry, and Behavior
October 1993
U Liminga, A E Johnson, P E Andrén et al.
Bilateral infusion of 5-hydroxytryptamine (5-HT) agonists into the substantia nigra pars reticulata (SNr) of awake rats was shown to influence oral behavior. The 5-HT1A agonist (R)-8-hydroxy-2-(di-propylamino)- tetralin (8-OH-DPAT) (1.3-13 nmol on each side) produced a dose-dependent depression of vacuous chewing movements (VCMs) that lasted about 20 min. The (R)-8-OH-DPAT-induced depression of...
Psychiatric Bulletin
December 1, 1992
Stefan Cembrowicz
Use ofQat in the UKDEARSIRS A recent newspaper article (The Independent, 1992) suggested that the plight of some Somalian refugees in this country is compounded by the adverse effects of heavy use of Qat, a mood-altering plant.Last year I encountered an acute psychotic episode associated with the use of Qat.My patient, a 28-year old Somalian male student, was brought to me by friends concerned...