Article reporting an experience in the course of electroconvulsive therapy (ECT) that was indistinguishable from a near-death experience (NDE). Aspects of the experience that had been terrifying for the individual were counterbalanced by her immediate and complete recovery from a suicidal depression. Beyond the transpersonal aspects of her NDE-like experience, the ECT triggered a precognitive...
Frontal-subcortical circuits provide a comprehensive framework for understanding the anatomy, biochemistry, and pharmacology of behavior. The three principal behaviorally relevant circuits originate in the dorsolateral prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex, respectively. Circuit-specific marker behaviors associated with each circuit are executive dysfunction...
Although the Tellegen Absorption Scale has been widely employed in recent years as a measure of personality Trait Absorption, it is argued that this simple score does not sufficiently discriminate true capacity for Absorption nor does it reveal the level of opportunity made for absorptive experiencing. This study operationalizes Capacity and Opportunity as two additional subscales appended to...
CP 55,940 is a potent synthetic bicyclic cannabinoid analog that has been used in a number of studies as a radioligand for the cannabinoid receptor. This compound shares behavioral and biochemical properties with naturally occurring cannabinoids such as delta 9-THC. The purpose of the present study was 3-fold: to establish the ability of CP 55,940 to serve as a discriminative stimulus, to...
PsychopharmacologyFebruary 1, 1995P J Armstrong, C Morton, W Sinclair et al.
In this six-period randomised double-blind study, 12 healthy volunteers inhaled mixtures of nitrous oxide at concentrations of 0% (placebo); 3%, 5%, 7%, 10%, and 15% in oxygen. Each concentration was inhaled for 55 min, each period being on a separate day. The order of treatments was randomised using a Latin-Square design. The effects of nitrous oxide were assessed using a battery of...
There is encouraging evidence that structured psychological treatments for depression, in particular cognitive therapy, can reduce subsequent relapse after the period of initial treatment has been completed. However, there is a continuing need for prophylactic psychological approaches that can be administered to recovered patients in euthymic mood. An information-processing analysis of...
Autoscopy is defined here as a visual experience where the subject sees an image of him/herself in external space, viewed from within his/her own physical body. This paper reviews the literature both historically and conceptually, and includes a quantitative study of accumulated cases. Cases published since 1935 and meeting the above definition for autoscopy (n = 53) were included, together...
Two adolescents with a long history of abuse of lysergic acid diethylamide (LSD) and symptoms consistent with major depressive disorder, on initiation of antidepressant therapy with selective serotonin reuptake inhibitor agents, had the new onset or worsening of LSD flashback syndrome. The similarity in neuroreceptor physiology for both LSD and serotonin suggests that the LSD flashback syndrome...
The effects of naloxone on the mood-altering and psychomotor-impairing effects of nitrous oxide were examined in two studies. Each of the double-blind, randomized trials tested effects of three doses of naloxone or saline placebo during inhalation of 30% nitrous oxide in oxygen or 100% oxygen placebo. Experiment 1 tested a range of naloxone doses used clinically to reverse opiate-induced...
The purpose of the proposed treatment program is to provide a holistic, natural approach to prevent alcohol and drug abuse among high-risk preadolescent and adolescent children by reducing psychological distress and physiological imbalance, and by enhancing protective resources through an individual and family program. To achieve this goal, juveniles referred for alcohol and drug abuse...