Neuroimage
December 20, 2012
Jonathan Smallwood, Christine M. Tipper, Kevin Brown et al.
145 citations
Cognition that is not based on perception can lead to at least two different outcomes. In some situations, cognition that is independent of perception can allow actions to be selected other than those prescribed by immediate perceptual input. In others, cognition can be independent of perception and unrelated to the current behavioral goal allowing thoughts to develop that are largely...
Pain
October 29, 2012
Marco L. Loggia, Jieun Kim, Randy L. Gollub et al.
319 citations
Neuroimaging studies have suggested the presence of alterations in the anatomo-functional properties of the brain of patients with chronic pain. However, investigation of the brain circuitry supporting the perception of clinical pain presents significant challenges, particularly when using traditional neuroimaging approaches. While potential neuroimaging markers for clinical pain have included...
Social Cognitive and Affective Neuroscience
October 9, 2012
An extensive body of research defines the default-mode network (DMN) to be one of the critical networks of the human brain, playing a pivotal functional role in processes of internal mentation. Alterations in the connectivity of this network as a function of aging have been found, with reductions associated with functional ramifications for the elderly population. This study examined...
Journal of Neuroscience
October 3, 2012
Miriam Kron, C James Howell, Ian T Adams et al.
Excitatory-inhibitory imbalance has been identified within specific brain microcircuits in models of Rett syndrome (RTT) and other autism spectrum disorders (ASDs). However, macrocircuit dysfunction across the RTT brain as a whole has not been defined. To approach this issue, we mapped expression of the activity-dependent, immediate-early gene product Fos in the brains of wild-type (Wt) and...
Neuroimage
September 18, 2012
Dimitrios Kapogiannis, David A. Reiter, Auriel A. Willette et al.
212 citations
The balance between excitatory glutamatergic projection neurons and inhibitory GABAergic interneurons determines the function of cortical microcircuits. How these neurotransmitters relate to the functional status of an entire macro-scale network remains unknown. The posteromedial cortex (PMC) is the default mode network (DMN) node with the greatest functional connectivity; therefore, we...
Teorie vědy / Theory of Science
August 20, 2012
Marek Havlík
The paper focuses on methodological and historical analysis of historical events that shaped the previous and current research of neurology. In 2001 Marcus Raichle came with a surprising discovery, which is now widely known as the Default Mode Network (DMN). DMN brings new knowledge about brain activity and it also changes traditional beliefs about the brain. The scientific community had...
The open neuroimaging journal
July 27, 2012
A. Fingelkurts, Sergio Bagnato, Cristina Boccagni et al.
The default mode network (DMN) has been consistently activated across a wide variety of self-related tasks, leading to a proposal of the DMN’s role in self-related processing. Indeed, there is limited fMRI evidence that the functional connectivity within the DMN may underlie a phenomenon referred to as self-awareness. At the same time, none of the known studies have explicitly investigated...
Annual Review of Clinical Psychology
March 29, 2012
Susan Whitfield-Gabrieli, Judith M. Ford
1,485 citations
Neuropsychiatric disorders are associated with abnormal function of the default mode network (DMN), a distributed network of brain regions more active during rest than during performance of many attention-demanding tasks and characterized by a high degree of functional connectivity (i.e., temporal correlations between brain regions). Functional magnetic resonance imaging studies have revealed...
International Journal of Clinical and Experimental Hypnosis
March 24, 2012
Quinton Deeley, David A Oakley, Brian Toone et al.
149 citations
Debate regarding the neural basis of the hypnotic state continues, but a recent hypothesis suggests that it may produce alterations in the default mode network (DMN). DMN describes a network of brain regions more active during low-demand compared to high-demand task conditions and has been linked to processes such as task-independent thinking, episodic memory, semantic processing, and...
Social Cognitive and Affective Neuroscience
March 24, 2012
Véronique A. Taylor, Véronique Daneault, Joshua A Grant et al.
317 citations
Mindfulness meditation has been shown to promote emotional stability. Moreover, during the processing of aversive and self-referential stimuli, mindful awareness is associated with reduced medial prefrontal cortex (MPFC) activity, a central default mode network (DMN) component. However, it remains unclear whether mindfulness practice influences functional connectivity between DMN regions and,...