BMJ
November 24, 2005
Samson S. Y. Wong, Kwok‐Yung Yuen
2 citations
Abstract 5-Methoxy-N,N-dimethyltryptamine (acronymized as 5-MeO-DMT) is sui generis among the numerous naturally-occurring psychoactive substances due to its unparalleled ego-dissolving effects which can culminate in a state of nondual consciousness (which is phenomenologically similar to transformative peak experiences described in various ancient contemplative traditions, e.g., Advaita...
Proceedings of the National Academy of Sciences
December 27, 2002
Michael D. Greicius, B. Krasnow, Allan L. Reiss et al.
Functional imaging studies have shown that certain brain regions, including posterior cingulate cortex (PCC) and ventral anterior cingulate cortex (vACC), consistently show greater activity during resting states than during cognitive tasks. This finding led to the hypothesis that these regions constitute a network supporting a default mode of brain function. In this study, we investigate three...
Neurology
September 1, 1964
Lawrence C. McHenry
35 citations
Abstract In recent years, specific cortical networks have been proposed to be crucial for sustaining consciousness, including the posterior hot zone and frontoparietal resting state networks (RSN). Here, we computationally evaluate the relative contributions of three RSNs – the default mode network (DMN), the salience network (SAL), and the central executive network (CEN) – to consciousness and...
BMJ
August 18, 1951
Peter Abbott
Abstract Background Neuroimaging studies have just begun to explore the acute effects of psychedelics on large-scale brain networks’ functional organization. Even less is known on the neural correlates of subacute effects taking place days after the psychedelic experience. This study explores the subacute changes of primary sensory brain networks and networks supporting higher-order affective...
Elizabeth J Davies, Natalie Ertl, Tom P. Freeman et al.
Adolescence is a critical period of brain development during which the endocannabinoid system continues to mature. These developmental changes may contribute to age-related differences in the association between cannabis use and large-scale functional network organisation, yet this association remains incompletely characterised. We hypothesised that regular cannabis use would be associated with...
Mouhammad Ousmane Ndiaye
Roughly 40% of patients with post-traumatic stress disorder (PTSD) and roughly 31% of patients with major depressive disorder (MDD) fail to respond to first-line treatment, and the two disorders co-occur in approximately half of all cases. No objective, nocturnal biomarker currently distinguishes which patients will fail to recover, or why. This paper proposes that a subgroup of...
Ceyda Sayalı
preprint
Classic psychedelics such as psilocybin and LSD are known to acutely disrupt executive function, producing impairments in response inhibition, working memory, and cognitive flexibility. Paradoxically, these compounds often lead to lasting improvements in cognitive flexibility, insight, and goal-directed behavior in the days and weeks following administration. This apparent contradiction has...
Taha Hanoglu, Halil Aziz Velioğlu, Behram Ali Salar et al.
preprint
ABSTRACT: Background: Charles Bonnet syndrome (CBS) is a prototype phenomenon for investigating complex visual hallucination. Our research focuses on resting state neural networks features of CBS patients with a comparison of patients with equally matched visual loss and healthy subjects in order to investigate the mechanism behind complex visual hallucinations. Material and Methods: Four CBS...
Gillian Grennan, Pragathi Balasubramani, Vojislav Maric et al.
preprint
Abstract Interoceptive attention to internal sensory signals is fundamental to mindfulness. In an attention-to-breathing task in 161 adults, we found that consistency of interoceptive attention significantly correlated with performance efficiency across several exteroceptive cognitive domain tasks. EEG source mapping within subjects showed that on low-consistency or distracted trials there was...
Sui Hsien Wong, Giuseppe Pontillo, Baris Kanber et al.
preprint
Background: Visual Snow Syndrome (VSS) is a neurological disorder of functional network dysregulation, with no published treatment trials to date. We set out to assess the feasibility of Mindfulness-Based Cognitive Therapy for visual symptoms (MBCT-vision) for VSS. Methods: A prospective open-label treatment trial. Primary Outcomes: self-rated symptom questionnaires (baseline vs week-9,...