European Neuropsychopharmacology
September 1, 2021
Martin K Madsen, Dea S Stenbæk, Albin Arvidsson et al.
132 citations
The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased...
Frontiers in Aging Neuroscience
August 27, 2021
Gunes Sevinc, Johann Rusche, Bonnie Wong et al.
Maintaining optimal cognitive functioning throughout the lifespan is a public health priority. Evaluation of cognitive outcomes following interventions to promote and preserve brain structure and function in older adults, and associated neural mechanisms, are therefore of critical importance. In this randomized controlled trial, we examined the behavioral and neural outcomes following...
European Journal of Neuroscience
August 1, 2021
Jun-Ichi Uemura, Aiko Hoshino, Go Igarashi et al.
Conscious perception of a near-threshold (NT) stimulus is characterized by the pre- and post-stimulus brain state. However, the power of pre-stimulus neural oscillations and strength of post-stimulus cortical activity that lead to conscious perception have rarely been examined in individual cortical areas. This is because most previous electro- and magnetoencephalography (EEG and MEG,...
Philosophy of Psychedelics
August 1, 2021
Chris Letheby
‘The role of self-representation’ presents three lines of evidence in support of a simple hypothesis: the central mechanism of psychedelic therapy is the disruption and revision of mental representations of the self. One line of evidence connects experiences of ‘psychological insight’ to positive clinical outcomes, and the insights in question are often autobiographical in character. A second...
Proceedings of the National Academy of Sciences
July 23, 2021
Lennart R.b. Spindler, Andrea I. Luppi, Ram Adapa et al.
Significance Understanding the neural bases of consciousness is of basic scientific and clinical importance. Human neuroimaging has established that a network of interconnected brain regions known as the default mode network disintegrates in anesthesia and after brain damage that causes disorders of consciousness. However, the neurochemical underpinnings of this network change remain largely...
The Journal of Nervous and Mental Disease
July 21, 2021
Yingqi Gu, Yi Zhu, Kirk Warren Brown
12 citations
ABSTRACT: Understanding the underlying mechanisms of mindfulness has been a hot topic in recent years, not only in clinical fields but also in neuroscience. Most neuroimaging findings demonstrate that critical brain regions involved in mindfulness are responsible for cognitive functions and mental states. However, the brain is a complex system operating via multiple circuits and networks,...
Proceedings of the National Academy of Sciences
July 16, 2021
Josef Parvizi, Rodrigo M. Braga, Aaron Kucyi et al.
59 citations
Significance In this manuscript, we report a rare case of a patient with localized seizures originating from the right anterior and dorsal posteromedial cortex (PMC). We mapped the electrophysiological and neuroimaging connectivity of the ictal onset site and replicated seizure auras by stimulating the homotopical PMC site in the left hemisphere. Our findings provide a causal link between PMC...
Neuropsychoanalysis
July 3, 2021
Andrei Novac, Barton J. Blinder
ABSTRACT Free association is still widely accepted as a fundamental component of psychoanalysis. However, despite notable advances in cognitive science, only a limited number of studies of free association by means of neurological methods exist. This review surveys a representative sample of neuroimaging studies on free association available to this date. Neuroimaging findings on free...
British Journal of General Practice
June 24, 2021
Emma Presern
1 citation
I’ve always been drawn to specialties where medicine can be practised holistically. It’s one of the reasons I applied for GP training and am currently undertaking a diploma in lifestyle medicine. My last post as a second-year GP trainee was a 6-month placement in palliative medicine at a well-known inner London hospice. While on this rotation, I came across patients who suffered with ‘total...
Frontiers in Psychiatry
June 11, 2021
Steven M. Silverstein, Adriann Lai
Schizophrenia is characterized by visual distortions in ~60% of cases, and visual hallucinations (VH) in ~25-50% of cases, depending on the sample. These symptoms have received relatively little attention in the literature, perhaps due to the higher rate of auditory vs. visual hallucinations in psychotic disorders, which is the reverse of what is found in other neuropsychiatric conditions....