Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology September 1, 2021 Martin K Madsen, Dea S Stenbæk, Albin Arvidsson et al. 132 citations
The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased...