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Routledge eBooks April 28, 2025 Charmaine Husum
This chapter explores the profound effects that non-ordinary states, particularly those induced by psychedelics, have on the brain. It highlights how psychedelics influence neural pathways, rerouting them to foster personal growth and address conditions like addiction and depression. Key mechanisms, such as the suppression of the default mode network (DMN), increased brain connectivity, and...
arXiv Preprint Archive April 25, 2025 Shirmohammad Tavangari, Sajjad Janfaza, Zahra Shakarami et al. preprint
This paper introduces a biomathematical model designed to describe the internal dynamics of dream formation and spontaneous cognitive processes. The model incorporates neurocognitive factors such as dissatisfaction, acceptance, forgetting, and mental activity, each of which is linked to established neural systems. We formulate a system of differential equations to simulate interactions among...
Neuropsychopharmacology April 19, 2025 Valeria Grasso, Joseph Tennyson, Raag D. Airan et al. 5 citations
Subanesthetic ketamine is currently used as a rapid-acting treatment for varied neuropsychiatric disorders. However, the mechanistic underpinnings of its therapeutic action remain unclear, and emerging clinical and preclinical evidence highlights a potential involvement of the opioid system. We used pharmacological functional ultrasound imaging data acquired during and after ketamine...
Journal of Psychedelic Studies April 17, 2025 Jacob T. Dines
AbstractBackground and aimsPsychedelic and MDMA-assisted psychotherapy are at the forefront of new treatment models for mental illnesses such as PTSD and depression, as well as improving well-being. Mindfulness meditation and loving-kindness meditation have also gained research traction, showing promise for enhancing emotional regulation and psychological well-being. This paper explores the...
Academia Mental Health and Well-Being April 14, 2025 Bence Szaszkó, Ulrich S. Tran
Meditation, traditionally seen as a path to spiritual enlightenment, is commonly used in therapeutic contexts for its mental health benefits, such as reducing stress, anxiety, and depression. However, alongside these benefits, practitioners of diverse forms of meditation have repeatedly been reporting adverse effects (AEs) of meditation. While most of these AEs are transient, some of them are...
Psychopharmacology April 11, 2025 Swanti Gupta, Raj K Bhatnagar, Dinesh Gupta et al. 27 citations
N, N-Dimethyltryptamine (DMT), a potent serotonergic psychedelic, bridges ancient wisdom and modern science. The mechanisms underlying its powerful psychedelic effects and out-of-body experiences continue to intrigue scientists. The functional role of DMT remains ambiguous. This paper explores the endogenous presence of DMT in the human body and its diverse neuroregulatory functions, which...
April 10, 2025 Debajyoti Ray preprint
This review examines the neuropsychological basis of somatic meditation, exploring its relationship with embodied cognition theories and its therapeutic potential. Somatic meditation, which cultivates focused attention on internal bodily sensations (interoception), is increasingly recognized for addressing the embodied aspects of stress, trauma, and chronic pain. Drawing on insights linking...
Journal of Medicine and Life Sciences April 5, 2025 Yuhang Qi, Bruce Park, Jian Madesen
Depression remains a leading cause of disability worldwide, with up to 40% of patients failing to achieve adequate response with conventional treatments. This paper introduces the Mindfulness-Acupuncture (MA) protocol, a pioneering 12-week intervention that systematically integrates acupuncture and mindfulness practices to address the multifaceted nature of depression. The theoretical framework...
Annals of Neurosciences April 2, 2025 Mannu Brahmi, Dushyant Soni, Shreya Sarkar et al. 9 citations
Breath-awareness practices contribute to stress management and psychological well-being among adolescents. However, their neurobehavioural effects remain underexplored, specifically in the Indian developmental context. This study examined how breath-based Ānāpānasati meditation affects brain electrical activity and the subjective self-reported experiences in adolescent novice meditators...
The British Journal of Psychiatry April 2, 2025 Wei-Chen Lin, Li-Kai Cheng, Tung-Ping Su et al. 2 citations
Evidence suggests the crucial role of dysfunctional default mode (DMN), salience and frontoparietal (FPN) networks, collectively termed the triple network model, in the pathophysiology of treatment-resistant depression (TRD). Using the graph theory- and seed-based functional connectivity analyses, we attempted to elucidate the role of low-dose ketamine in the triple networks, namely the DMN,...