Nature Communications
June 4, 2019
T. Pascoal, S. Mathotaarachchi, M. Kang et al.
The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission tomography ([18F]florbetapir tracer for Aβ and [18F]FDG tracer for glucose metabolism) with a novel analytical framework, we found that Aβ aggregation within the brain’s default mode network leads to regional hypometabolism in distant but...
Journal of Alzheimer's Disease
June 4, 2019
L. Eyler, J. Elman, S. Hatton et al.
Background: Large-scale brain networks such as the default mode network (DMN) are often disrupted in Alzheimer’s disease (AD). Numerous studies have examined DMN functional connectivity in those with mild cognitive impairment (MCI), a presumed AD precursor, to discover a biomarker of AD risk. Prior reviews were qualitative or limited in scope or approach. Objective: We aimed to systematically...
Journal of Pain
June 1, 2019
Richard Harrison, Fadel Zeidan, George Kitsaras et al.
Mindfulness-based training reduces pain in clinical and experimental settings. Evidence suggests that these beneficial effects are facilitated via an increased focus on the present moment and a reduced emotional enhancement of pain. Most of the existing literature has focused on mindfulness as a learned skill and on the neural mechanisms that underlie the acquisition of this skill. It is...
Human Brain Mapping
May 7, 2019
Michiel van Elk, M. Andrea Arciniegas Gomez, Wietske van der Zwaag et al.
122 citations
Abstract In the present fMRI study, we aimed to obtain insight into the key brain networks involved in the experience of awe—a complex emotion that is typically elicited by perceptually vast stimuli. Participants were presented with awe‐eliciting, positive and neutral videos, while they were instructed to get fully absorbed in the scenery or to count the number of perspective changes. By using...
European Neuropsychopharmacology
May 1, 2019
Reham Fahmy, Maha Wasfi, Rania Mamdouh et al.
Recently, mindfulness-based programs have shown promising clinical effects in the treatment of substance-use disorders (SUD). While several studies linked mindfulness to decreased default mode network (DMN) connectivity in meditators, only a few studies investigated its effects in patients with SUD. This study aimed to detect changes in DMN connectivity in opiate dependent patients receiving...
Nature Communications
April 29, 2019
Cirong Liu, Cecil Chern-Chyi Yen, Diego Szczupak et al.
127 citations
The default mode network (DMN) is associated with a wide range of brain functions. In humans, the DMN is marked by strong functional connectivity among three core regions: medial prefrontal cortex (mPFC), posterior parietal cortex (PPC), and the medial parietal and posterior cingulate cortex (PCC). Neuroimaging studies have shown that the DMN also exists in non-human primates, suggesting that...
Journal of Neural Transplantation and Plasticity
April 2, 2019
Ricardo Ramírez-Barrantes, M. Arancibia, Jana Stojanova et al.
Aging is a physiological process accompanied by cognitive decline, principally in memory and executive functions. Alterations in the connectivity of the default mode network (DMN) have been found to participate in cognitive decline, as well as in several neurocognitive disorders. The DMN has antisynchronic activity with attentional networks (task-positive networks (TPN)), which are critical to...
Scientific Reports
February 4, 2019
Timmy Strauss, Robin Kämpe, J. Paul Hamilton et al.
Abstract: Interpersonal touch possesses a strong affective component, which immediately evokes attention. The neural processing of such touch is moderated by specialized C-tactile nerve fibers in the periphery and results in central activation of somatosensory areas as well as regions involved in social processing, such as the superior temporal gyrus (STG). In the present functional...
Cortex
January 30, 2019
Yelena G Bodien, Zachary D. Threlkeld, Brian L Edlow
Compared Notably, DMN properties were completely absent in Patient 4 (P4), who had a behavioral diagnosis of VS but demonstrated covert consciousness on a functional magnetic resonance imaging (fMRI) motor imagery task. A yellow outline of the brain indicates an intact DMN property, defined by a Z-value (for correlations and anticorrelations) and percent of suprathreshold voxels (for...
arXiv Preprint Archive
January 28, 2019
Yunlong Nie, Eugene Opoku, Laila Yasmin et al.
preprint
We conduct an imaging genetics study to explore how effective brain connectivity in the default mode network (DMN) may be related to genetics within the context of Alzheimer's disease and mild cognitive impairment. We develop an analysis of longitudinal resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data obtained from a sample of 111 subjects with a total of 319...
Neuroscience & Biobehavioral Reviews
2019
Grace Blest‐hopley, Vincent Giampietro, Sagnik Bhattacharyya
HighlightsAdolescent abstinent cannabis users showed significantly greater activation in the dorsolateral and ventrolateral prefrontal and posterior parietal cortices compared to controls.Adolescent users showed increased activation in regions involved in executive functioning, attentional control and the default mode network compared to non‐using controls.No significant group differences in...
International Journal of Yoga
2019
Reshma Madhukar Shetkar, Alex Hankey, Hr Nagendra et al.
Important stages of creativity include preparation, incubation, illumination, and verification. Earlier studies have reported that some techniques of meditation promote creativity but have not specified which stage is enhanced. Here, we report the influence of cyclic meditation (CM) on creative cognition measured by a divergent thinking task. Our aim was to determine the degree of association...