The main psychoactive component of marijuana, Delta9-tetrahydrocannabinol (THC), acts in the CNS via type 1 cannabinoid receptors (CB1Rs). The behavioral consequences of THC or synthetic CB1R agonists include suppression of motor activity. One explanation for movement suppression might be inhibition of striatal dopamine (DA) release by CB1Rs, which are densely localized in motor striatum;...
In investigations of the molecular determinants for the recognition of drugs by a serotonin (5-HT) receptor in the brain, the commonality in the reactivity patterns of 5-HT congeners has been identified. On this basis a mechanistic hypothesis is proposed to explain the rank order of the affinity of drugs that bind to the receptor shared by 5-HT and LSD (the 5-HT/LSD receptor). This hypothesis...