The International Journal of Neuropsychopharmacology
September 1, 2026
Z. Li, D. Mukherjee, E. Dempster et al.
Abstract Background Adolescent cannabis use is associated with an increased risk of psychosis, yet the underlying molecular mechanisms remain poorly understood. Emerging evidence also pointed to genetic liability shaping individual risk of cannabis-induced psychosis. The neuregulin–ErbB4 signalling pathway, implicated in schizophrenia-related neurodevelopment, may modulate individual...
Clinical Neuropsychopharmacology and Addiction
September 1, 2026
Beatrice Dal Bianco, Matteo Buonarroti, Alessandro Lo Jacono et al.
Background: Epidemiological data on psychedelic use in Italy is limited. In this study, Italian responders in the Global Psychedelic Survey 2025 were subanalyzed to describe patterns of use, motivations, subjective experiences, and health correlates. Methods: Adults (≥21 years) with lifetime psychedelic exposure, residing in or born in Italy or San Marino, were surveyed in a web-based,...
DELOS Desarrollo Local Sostenible
August 31, 2026
Ricardo Cavalari Dória, Romulo Ronsani Ferreira, Maria Eugenia Garavello et al.
O uso de ayahuasca vem se expandindo no Brasil para além do contexto religioso tradicional, alcançando também padrões recreativos, com riscos psiquiátricos ainda pouco documentados na literatura nacional. Este relato descreve o caso de uma paciente de 28 anos, com Transtorno Afetivo Bipolar (CID-10 F31.2) diagnosticado havia nove anos e três internações prévias por mania psicótica, internada...
Psychiatry research communications
August 28, 2026
Laura A. Steenhuis, Johanna T. W. Wigman, Ellen Visser et al.
Background Auditory hallucinations (AH) are subclinical psychotic experiences occurring in childhood and adulthood. Although common in childhood, their long-term course and impact on adult mental health remain unclear. This study presents the third, 18-year follow-up of a population-based case–control cohort originally including children aged 7–8 years reporting AH, examining (i) the 18-year...
Health Affairs Scholar
August 27, 2026
Danielle R Adams, Morgan Hartman, Lisa Gong et al.
Abstract Introduction Oregon is the first US state to permit supervised psilocybin services through a nonmedical, wellness-based model. We examined what prospective clients with psychiatric histories encounter when contacting service centers, including how staff communicate about safety, eligibility, and cost. Methods We conducted a mystery shopper study of 26 licensed service centers in Oregon...
bioRxiv
August 12, 2026
Ru-Yi Cai, Yue-Qi Yang, Shang-Xuan Cai et al.
preprint
The endocannabinoid system modulates diverse physiological processes via two endogenous lipid ligands, 2-arachidonoylglycerol (2-AG) and anandamide (AEA); however, their specific spatiotemporal dynamics remain poorly understood owing to the lack of selective probes. Here, we developed GRAB2-AG2.0 and GRABAEA2.0, two genetically encoded fluorescent sensors that selectively detect 2-AG and AEA,...
Addictive Behaviors
August 1, 2026
Sarret Seng, Chizimuzo T C Okoli, Lovoria B Williams et al.
Metacognition - the capacity to monitor, interpret, and regulate cognitive processes - is essential for adaptive behavioral regulation. Evidence on how substance use relates to metacognitive functioning remains heterogeneous across substances and study designs. This systematic review synthesized evidence examining the relationship between substance use and metacognition among adults. Following...
International Journal of Independent Research Studies
July 31, 2026
Eric P. Rubenstein
Recreational substance use can produce acute panic and distress even when no severe toxicological emergency is immediately evident. Existing literature commonly treats cannabis-related anxiety, stimulant intoxication, MDMA-related complications, cocaine-related cardiovascular risk, ketamine-related dissociation, and psychedelic challenging experiences as separate domains. This article...
Revista Brasileira de Cannabis
July 22, 2026
Amanda Rebeca Pinto Marambaia
INTRODUÇÃO: A relação entre Cannabis e meio ambiente transcende a dimensão produtiva, conectando-se às lutas por autonomia terapêutica em territórios tradicionais. Este estudo analisa a experiência do Assentamento Terra Vista (BA), vinculado à Teia dos Povos, onde o uso comunitário de óleo de cannabis emerge como prática de cuidado alinhada à construção de territórios livres. OBJETIVO: Relatar...
Frontiers in Psychiatry
July 21, 2026
David Martinez Garza, Ilya O. Blokhin, Jonathan Brett et al.
Since the introduction of disulfiram in 1951 (the first ever Food and Drug Administration (FDA)-approved medication for substance use disorders (SUDs)) (1), only seven other individual medications have been approved for the treatment of SUDs. While the repurpose of medications and different formulations increase the total number of FDA-approved medicines (Table 1 and(2)), the arsenal of...