Psychoactives
October 15, 2026
Felipe Heemann
Synthetic cannabinoids (SCs), marketed as Spice, K2, and dozens of successor compounds, constitute one of the most pharmacologically dangerous categories of new psychoactive substances (NPS) currently in circulation. Their extreme toxicity relative to Δ9-tetrahydrocannabinol (THC) is not fully accounted for by CB1 receptor pharmacokinetics alone. This review proposes an integrative mechanistic...
Current Sexual Health Reports
October 7, 2026
Suzanne Mulvehill
Abstract Purpose of Review Female orgasmic disorder/difficulty (FOD) remains prevalent, yet treatments are limited and outcomes variable. Traditional approaches have focused primarily on stimulation, behavioral techniques, sex therapy, and psychological processes, without fully accounting for state-dependent and non-genital pathways through which orgasm may become accessible. These pathways may...
npj Heritage Science
October 3, 2026
Yuanchun Song, Yongqiang Wang, Yunpeng Tang et al.
This study aimed to investigate the function of a wooden brazier excavated from the Hongshan Cemetery (5th to 3rd century BC) in Xinjiang, northwestern China. Organic residues and material composition were analysed using gas chromatography-mass spectrometry (GC-MS) and wood anatomical analysis to identify burned plant resources and explore their cultural significance. GC-MS results confirmed...
International Journal of Homoeopathic Sciences
October 1, 2026
Diyaana Z Crri, R Sakthi, R Samaran
Hallucinations are disturbances of perception in which a person experiences vivid sensory phenomena even though there is no corresponding external stimulus. They can involve different sensory modalities, including hearing voices or sounds, seeing people or objects, perceiving unusual smells or tastes, or experiencing sensations of touch or bodily movement. Although hallucinations are frequently...
Psychiatry Research
October 1, 2026
Jaime Rojas-Hernández, Lucas F Borkel, Ángelo Santana Del Pino et al.
This study examines acute and delayed adverse reactions reported in naturalistic psychedelic use, focusing on their associations with substance-use patterns, contextual variables, and user motivations. Using an online survey incorporating the Psychedelic Use Scale, data were collected from a large naturalistic sample (N=1022) to analyze patterns of self-reported adverse reactions. Acute adverse...
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
September 25, 2026
Baobao Shi, Haitao Wang, Wenhua Zhou et al.
To elucidate the Δ9-tetrahydrocannabinol (THC)-like discrimina-tive stimulus effects of 4F-ABUTINACA and to investigate the potential mechanisms underlying anxiety-like behaviors induced by chronic 4F-ABUTINACA administration. A THC drug discrimination procedure was employed in six adult male Sprague-Dawley rats to assess the THC-like discriminative stimulus effects of 4F-ABUTINACA and to...
Substance Use & Misuse
September 19, 2026
Cassidy R Loparco, Kayla K Tillett, Matthew E Rossheim et al.
Objective: Amanita muscaria mushrooms, known for their hallucinogenic effects, have grown in popularity and availability. However, use can cause delirium, coma, and death. Moreover, the US Food and Drug Administration (FDA) has stated that Amanita muscaria, its extracts, and certain constituents (muscimol, ibotenic acid, and muscarine) are unapproved additives that do not meet the Generally...
Figshare
September 19, 2026
Cassidy R Loparco, Kayla K Tillett, Matthew E Rossheim et al.
preprint
Amanita muscaria mushrooms, known for their hallucinogenic effects, have grown in popularity and availability. However, use can cause delirium, coma, and death. Moreover, the US Food and Drug Administration (FDA) has stated that Amanita muscaria, its extracts, and certain constituents (muscimol, ibotenic acid, and muscarine) are unapproved additives that do not meet the Generally Recognized as...
Journal of Contemplative Studies
September 10, 2026
Stuart Sarbacker
In this paper, I examine the relationship between the mind-body disciplines of Hindu, Buddhist, and Jain systems of yoga, focusing on the use of psychoactive substances in the Indic religious context and the ways that modern cosmopolitan forms of yoga have been intersected with the use of psychedelic substances.The foundation of the study is a comparative examination of the semantic field of...
medRxiv
September 10, 2026
Mori Krantz, Mark C. Haigney, Mary Ross Southworth et al.
preprint
Background: Several Schedule I substances have demonstrated potential benefits for refractory psychiatric conditions and addiction. Some have been legalized at the state level, while others like kratom (mitragynine) are available over-the-counter in some states and illegal in others. A recent presidential executive order directs certain federal agencies to accelerate development and facilitate...