American Journal of Psychiatry
October 1, 2001
Rodney J. Croft, A. Klugman, Torsten Baldeweg et al.
100 citations
These data show that 5-HT dysfunction occurs in MDMA users, is related to users' MDMA consumption, and is independent of cannabis use. The results do not suggest that self-medication explains this relationship, because the deficit was related to total MDMA consumption but not frequency of consumption. The results are thus consistent with the thesis that MDMA consumption causes 5-HT impairment...
Journal of Psychopharmacology
May 1, 2001
Nicholas Macinnes, Sheila L. Handley, G. F. A. Harding
120 citations
Previous work has indicated recreational use of methylenedioxymethamphetamine (MDMA or ecstasy) is associated with elevated scores on self-report measures of depression. We sought to examine the long-term effects of consumption on depression in a group of individuals who had consumed large quantities of the drug in the past, but were now leading relatively drug free lives. Respondents to this...
Journal of Neurology, Neurosurgery, and Psychiatry
June 1, 2000
Euphrosyne Gouzoulis‐mayfrank
309 citations
The present data raise concern that use of ecstasy possibly in conjunction with cannabis may lead to cognitive decline in otherwise healthy young people. Although the nature of the emerging cognitive disturbance is not yet clear, an impairment of working memory might be the common denominator underlying or contributing to declines of performance in various tasks. The cognitive disturbance is...
Archives of General Psychiatry
February 1, 1977
Leroy C. Gould
34 citations
Only recently have multiple-drug use studies involving more than heroin and marijuana begun to be reported in the literature. Four of these studies have found evidence that multiple-drug use is a progressive phenomenon, although the particular pattern of multiple-drug use reported in different populations varies somewhat. This study examines the patterns of multiple-drug use reported by a...
A M A Archives of Neurology & Psychiatry
June 1, 1956
Nicholas A. Bercel
35 citations
INTRODUCTION Experimental psychosis has a long history. It might have started with the administration of Cannabis indica boiling in wine to the ancient Hun warriors, resulting in mental obfuscation, as they were prepared for surgery because of wounds sustained in battle. Scientific experimental psychiatry began toward the end of the last century, in the Kraepelinian era—when the organic theory...
Irish Journal of Psychological Medicine
October 19, 2026
Sarah Lanigan, Níall Lally, Aoife Brett et al.
OBJECTIVES: To describe the demographic, clinical, and treatment characteristics of individuals admitted with hexahydrocannabinol (HHC)-associated psychosis and compare with cannabis-associated psychosis. METHODS: A retrospective chart review was undertaken of all admissions to the Adult Acute Mental Health Unit at University Hospital Galway, Ireland, between 1 May 2023 and 31 July 2025, with...
Psychopharmacology
October 17, 2026
Andreas Krabbe, Lena Lindström, Pilleriin Sikka et al.
Combining meditation with psychoactive substances is often assumed to be a niche practice centred on classic psychedelics. We sought to broaden this narrative in two cross-sectional studies. Study 1 used a broad naturalistic sample (N = 1,391) to examine the prevalence of substance use, meditation, and their simultaneous combination, as well as associations with subjective happiness. Study 2...
Psychoactives
October 15, 2026
Felipe Heemann
Synthetic cannabinoids (SCs), marketed as Spice, K2, and dozens of successor compounds, constitute one of the most pharmacologically dangerous categories of new psychoactive substances (NPS) currently in circulation. Their extreme toxicity relative to Δ9-tetrahydrocannabinol (THC) is not fully accounted for by CB1 receptor pharmacokinetics alone. This review proposes an integrative mechanistic...
Current Sexual Health Reports
October 7, 2026
Suzanne Mulvehill
Abstract Purpose of Review Female orgasmic disorder/difficulty (FOD) remains prevalent, yet treatments are limited and outcomes variable. Traditional approaches have focused primarily on stimulation, behavioral techniques, sex therapy, and psychological processes, without fully accounting for state-dependent and non-genital pathways through which orgasm may become accessible. These pathways may...
npj Heritage Science
October 3, 2026
Yuanchun Song, Yongqiang Wang, Yunpeng Tang et al.
This study aimed to investigate the function of a wooden brazier excavated from the Hongshan Cemetery (5th to 3rd century BC) in Xinjiang, northwestern China. Organic residues and material composition were analysed using gas chromatography-mass spectrometry (GC-MS) and wood anatomical analysis to identify burned plant resources and explore their cultural significance. GC-MS results confirmed...