Kaeli Zimmermann, Keith M. Kendrick, Dirk Scheele et al.
preprint
ABSTRACT Public perception of cannabis as relatively harmless, alongside claimed medical benefits, have led to moves towards its legalization. Yet, long-term consequences of cannabis dependence, and whether they differ qualitatively from other drugs, are still poorly understood. A key feature of addictive drugs is that chronic use leads to adaptations in reward processing, blunting responsivity...
Emese Kroon, Yara J Toenders, Lauren Kuhns et al.
preprint
Background. The global increase in lenient cannabis policy has been paralleled by reduced harm perception, which has been associated with cannabis use initiation and persistent use. However, it is unclear how cultural attitudes towards cannabis use might affect the brain processes underlying cannabis use. Methods. Resting state functional connectivity (RSFC) within and between the executive...
Carolyn M. Amir, Dara G. Ghahremani, Sarah E. Chang et al.
preprint
Abstract Importance Rates of prenatal cannabis exposure (PCE) are rising with increasingly permissive legislation regarding cannabis use, which may be a risk factor for psychosis. Disrupted reward-related neural circuitry may underlie this relationship. Objective To elucidate neural mechanisms involved in the association between PCE and youth-onset psychotic-like experiences by probing...
Abhinandan Banerjee, William Hosie, Ana Carolina Terso Ventura et al.
Background: This paper highlights the formulation of a solid THC-loaded ingestible prepared from pure THC distillate. A THC ethanol-assisted cannabinoid nanoemulsion (EACNE) was created without the need for specialized emulsification equipment such as a high-pressure homogenizer or a microfluidizer. Stress-testing was performed on the EACNE to evaluate its chemical and colloidal stability under...
Teneisha M. Myers, Noah C. Neverette, Aaron S. Devanathan et al.
preprint
Abstract Rationale Cannabis is the most widely used illicit substance in the United States, and its use is increasing with the recent push for legalization and decriminalization, as well as the growing use for medicinal purposes. While cannabis can have positive effects in some individuals, there are potential negative consequences including dependence, psychosis, and cognitive impairments. The...
Sara R Westbrook, Allison L Jensen, Vanessa Copeland-Solorzano et al.
preprint
Abstract The legalization of cannabis in several states across the US has increased the need to better understand its effects on the body, brain, and behavior, particularly in different populations. Rodent models are particularly valuable in this respect because they provide precise control over external variables. Previous rodent studies have found age and sex differences in response to...
Maurizio Coppola, Raffaella Mondola
preprint
Psychosis can be defined as a combination of psychopathological symptoms including delusions and/or hallucinations without insight. Psychotic disorders may configure a primary psychiatric illness or represent the result of a functional/structural brain damage induced by substance use, neurological diseases or other medical conditions. They are multifactorial disorders in which genetic,...
Fouad Meraji Far, Hamid Reza Banafshe, Amir Ghaderi et al.
preprint
Abstract Background The insula, a central hub of the salience network, is implicated in craving and loss of control in addiction. Despite its relevance, the structural morphometric and white matter connectivity correlates of chronic cannabis use remain inconsistent across studies. Methods Twenty-six all-male participants (13 chronic cannabis users, 13 controls) underwent a 3.0 Tesla MRI....
Neurochemical Research
August 27, 2026
Kazutoshi Yonemura, Nobue Kitanaka, Kazuo Tomita et al.
Cannabis, widely used for both medical and non-medical purposes, primarily contains Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Δ9-THC is the main driver of cannabis abuse and of psychological and physical dependence, whereas CBD has limited abuse potential and is even being investigated as a treatment for cannabis use disorder and other conditions. This review aims to clarify how...
Sciences of Phytochemistry
July 12, 2026
Fakhray Rimi, Jannatul Fardous, Fahmida Zaman et al.
Medicinal plants have been used in traditional medicine to alleviate a range of neurological and psychological disorders. Numerous plant-derived phytochemicals are known to modulate central nervous system activity by interacting with neurotransmitters, receptors, and neurochemical pathways. This review provides a comprehensive overview of medicinal plants with psychoactive properties, their...