Behavioural Pharmacology
July 2004
Scott D Lane, Don R Cherek, C J Pietras et al.
Acute marijuana administration may alter response-reinforcer relationships via a change in reinforcer efficacy, but may also impair coordination and motor function. One approach to evaluating drug effects on both motor function and reinforcer efficacy involves fitting the matching law equation to data obtained under multiple variable interval (VI) schedules. The present report describes an...
Praxis
June 2, 2004
Michael P Schaub, Wulf Rössler, Rudolf Stohler
The present review focuses on articles dealing with clinical or epidemiological studies on the association between cannabis use and psychoses. Included are all articles published since 1990 that were located by a Medline or Psyclit data-base research and those earlier articles that are needed for a correct understanding of studies published during the index episode. The three main topics found...
Epidemiologia e Psichiatria Sociale
June 1, 2004
Helene Verdoux, Marie Tournier
SummaryObjective – The nature of the link between cannabis use and psychosis remains to be clarified. Method – The paper reviews the evidence suggesting that cannabis may be a risk factor for psychosis onset. Results – Cross-sectional and retro- spective epidemiological studies show that individuals with psychosis use cannabis more often than other individuals in the gener- al population. It...
Cambridge University Press eBooks
May 27, 2004
Don H. Linszen, Bart D. Peters, Lieuwe de Haan
9 citations
As detailed elsewhere in this book (Chapter 3), cannabis has been used for centuries to produce euphoria and relaxation as desired mental effects. However, adverse effects of intoxication with cannabis include anxiety and panic (Thomas, 1996; Reilly et al. , 1998), depression (Bovasso, 2001; Patton et al. , 2002: see Chapter 4), and impairment in certain domains of cognitive function (see...
Cambridge University Press eBooks
May 27, 2004
Wayne Hall, Louisa Degenhardt
27 citations
There are good reasons to be concerned about the possibility that cannabis use may be a cause of psychotic disorders. Psychoses are serious and disabling disorders (Bromet et al. , 1995). Cannabis is widely used during late adolescence in many developed societies (Hall et al. , 1999), and high doses of tetrahydrocannabinol (THC) – the psychoactive substance in cannabis – have been reported to...
Neuropsychopharmacology
May 2004
Boris B. Quednow, Kai‐uwe Kühn, Klaus Hoenig et al.
Chronic administration of 3,4-methylenedioxymethamphetamine (MDMA) is associated with long-term depletion of serotonin (5-HT) and loss of 5-HT axons in the brains of rodents and nonhuman primates. Despite the broad database concerning the selective serotonergic neurotoxicity of recreational MDMA consumption by humans, controversy still exists with respect to the question of whether the...
Dangerous Harvest
April 22, 2004
James H. Mills
When approaching the subject of rural producers and their environments in nineteenth-century India, it is necessary to be mindful of the range of studies during the last 30 years or so that have emphasised the importance of resistance to colonial projects. These studies, most notably those published in the Subaltern Studies project (Guha 1982), have focused on the strategies and agendas of...
Addiction
March 25, 2004
Zerrin Atakan
2 citations
Sir—Does cannabis use cause a psychotic illness? About 150 years ago this question was already being asked, particularly recognizing the risk of ‘madness’ among young people, while at the same time the practice of using cannabis as a ‘medicine for insanity’ was being carried out in asylums (Mills 2003). It is interesting that over a century later the same question still remains unanswered,...
Molecular and cellular neurosciences
March 2004
Tiziana Rubino, Greta Forlani, Daniela Viganò et al.
Acute Delta(9)-tetrahydrocannabinol (THC) injection increased ERK pathway (ERK, pCREB, and c-fos) mostly in the caudate putamen and cerebellum. This effect underwent to homeostatic adaptation after chronic treatment. Moreover, chronic THC exposure induced increases in the ERK cascade (ERK, pCREB, and Fos B) in the prefrontal cortex and hippocampus, suggesting that different neuronal circuits...
Neuropsychopharmacology
March 2004
Christopher D. Verrico, J David Jentsch, Robert H Roth et al.
The residual neuropsychological effects of marijuana abuse in man indicate a dysfunction of the attentional/executive systems. Moreover, experimental investigations suggest that repeated, intermittent (subchronic) Delta(9)-tetrahydrocannabinol (THC), the main psychoactive ingredient of marijuana, alters neurotransmission in the frontal cortex of rats and humans, a key neural site mediating...