Objetivo: revisar a literatura sobre a associação entre uso de cannabis e o desenvolvimento de esquizofrenia. Metodologia: revisão sistemática da literatura realizada em bases de dados eletrônicas (PubMed e SciELO), que inclui revisões e estudos observacionais (estudos de coorte e cortes transversais) publicados no período de janeiro de 2000 a novembro de 2015, além de estudos encontrados...
Novel cannabinoid compounds continue to be marketed as "legal" marijuana substitutes, even though little is known about their molecular and behavioral effects. Six of these compounds (ADBICA, ADB-PINACA, THJ-2201, RCS-4, JWH-122, JWH-210) were tested for in vitro and in vivo cannabinoid-like effects to determine their abuse liability. Binding to and functional activity at CB1 cannabinoid...
Cannabis or marijuana is an illegal drug that is being used mostly by young adultscan have adverse effects i.e., dependence syndrome, impaired respiratory and cardiovascularfunctions, psychosocial and mental health disorders. Objective: The present study examinedthe effects of cannabis (including bhang & charas) consumption on emotional and cognitivedisturbances and depressive symptoms in young...
In pre-clinical models of marijuana abuse, there is relatively limited evidence of delta-9-tetrahydrocannabinol's (THC) rewarding effects, as indexed by its general inability to induce a place preference. One explanation for this failure is that its rewarding effects are masked by its concurrently occurring aversive properties. Consistent with this explanation, THC pre-exposure, which...
Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality from observational designs can be problematic. We review the evidence from longitudinal studies that have examined this relationship and discuss the epidemiologic evidence for and against interpreting the findings as causal. We also review the evidence identifying groups at...
Rationale Δ 9 ‐Tetrahydrocannabinol (THC) produces both aversive and rewarding effects in animal models. Given that the balance between a drug's affective properties is thought to underlie its abuse potential, it is important to consider these properties of THC and how they (and their balance) are impacted by various factors. In this context, previous studies have examined the effect of THC...
Back to table of contents Previous article Next article Clinical and Research NewsFull AccessResearch Identifies Gene Linked to Cannabis-Induced PsychosisNick ZagorskiNick ZagorskiSearch for more papers by this authorPublished Online:17 Mar 2016https://doi.org/10.1176/appi.pn.2016.3b53AbstractVariants in the AKT1 gene increase risk of acute psychotic symptoms, but another potential...
Heavy cannabis use is associated with reduced motivation. The basal ganglia, central in the motivation system, have the brain's highest cannabinoid receptor density. The frontal lobe is functionally coupled to the basal ganglia via segregated frontal-subcortical circuits conveying information from internal, self-generated activity. The basal ganglia, however, receive additional influence from...
BACKGROUND Although the link between cannabis use and development of psychosis is well established, less is known about the effect of continued versus discontinued cannabis use after the onset of psychosis. We aimed to summarise available evidence focusing on the relationship between continued and discontinued cannabis use after onset of psychosis and its relapse. METHODS In this systematic...
Previous studies have reported that peer groups are one of the most important predictors of adolescent and young adult marijuana use, and yet the neural correlates of social processing in marijuana users have not yet been studied. In the current study, marijuana-using young adults (n = 20) and non-using controls (n = 22) participated in a neuroimaging social exclusion task called Cyberball, a...