While cannabis has been reported to have many therapeutic utilisations, minimal studies have explored the use behaviours of individuals with ADHD in New Zealand. Due to the considerably high rates of cannabis use within this population, it is necessary that this gap in the literature is explored. Of the analyses that have been conducted, it appears that the self-medication hypothesis may...
Abstract Altered states of consciousness (ASC) refer to states that differ markedly from normal waking consciousness. ASC may occur spontaneously, such as in dreaming, or through consciousness modifying techniques, from meditation, to cannabis and psychedelics. The etymology behind the term psychedelic, meaning mind-manifesting, is based on the hypothesis that certain substances, including...
Brain Research BulletinAugust 1, 2026Barkha J. Yadav-Samudrala, Laith E. Sawaqed, Caitlin J. Huguely Wilkinson et al.
While combined antiretroviral therapy (cART) has transitioned HIV-1 into a manageable chronic condition, it fails to eradicate latent viral reservoirs in the central nervous system (CNS) that drive persistent neuroinflammation and synaptodendritic injury. Consequently, people living with human immunodeficiency virus type-1 (HIV-1) often utilize cannabis to manage neurological symptoms, yet the...
Psychiatry ResearchAugust 1, 2026C. Bharat, Xin-Tong Huang, G. Campbell et al.
BACKGROUND Interest in cannabinoids for mental and substance use disorders is increasing. We examined experimental and observational evidence for treating these disorders and their symptoms. METHODS Systematic review and meta-analysis (PROSPERO CRD42023467536). We searched CENTRAL, MEDLINE, Embase and PsycINFO to May 2025 for studies of cannabinoids in adults (≥18 years) with ADHD, anxiety,...
ABSTRACT Background Despite the high prevalence of comorbid cannabis use at first onset of psychotic symptoms, high transition rates from cannabis‐induced psychosis to schizophreniform psychoses and bipolar disorder, and evidence of cannabis use as a risk factor in developing primary psychosis, only a few studies have addressed the difficulties in differential diagnosis focusing on the early...
Introduction: Epidemiological data indicate that over half of people who consume cannabis report anxiety reduction as a reason for use. Anxiety is frequently cited as a primary motivation for cannabis use among both medical and recreational consumers. The lifetime prevalence of anxiety disorders in the United States is approximately 34% with more recent data suggesting that the figure may be as...
Adolescent substance use is associated with increased risk of suicide, overdose, and executive dysfunction. Alcohol and marijuana are the two most-used substances among young people. Substance use is associated with dysfunctional resting-state network connectivity between the default mode network (DMN), executive control network (ECN), and salience network (SN) and executive dysfunction. There...
BACKGROUND Increases in cannabis use, potency, and legal liberalization have raised concerns about psychiatric consequences. Previous studies suggest an association between cannabis use and earlier age at onset (AAO) of psychosis, but an updated meta-analysis is needed. METHODS MEDLINE, Embase, and PsycInfo were searched from inception to April 2025. Peer-reviewed cohort and case-control...
We know little about the extent psychedelic substances are consumed therapeutically and/or discussed with medical professionals despite renewed global interest in these substances. We examined self-reported responses from the 2023 International Cannabis Policy Study (ICPS) in repeated cross-sectional surveys in Canada, the United States, Australia, and New Zealand. The survey included questions...
Catatonia is a syndrome of psychomotor disturbance occurring in association with various psychiatric, medical, or substance-related conditions. In this report we describe a 31-year-old male with no past psychiatric history who presented with features of catatonia in the context of heavy cannabis use with recent escalation. This case highlights cannabis as a potential precipitant of catatonia...
Aim: This systematic review and meta-analysis examined the neuropsychiatric effects of cannabis, focusing on the contrasting roles of Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). It evaluated their associations with psychiatric outcomes, assessed the therapeutic potential of cannabis-based products (CBPs), and identified evidence gaps relevant to clinical practice and mental health...
In this study, a reaction pathway for converting the psychoactive compound Δ9-THC into the nonpsychoactive cannabidiol (CBD) was proposed. Related cannabinoids, including Δ8-THC and cannabinol (CBN), were also examined. The transformation proceeds via two key steps: (i) hydrogen elimination and cyclic ether ring cleavage, and (ii) hydrolysis to form hydroxyl groups, facilitated by boron...
Revista Brasileira de CannabisJuly 22, 2026Cláudio Yuri Rodrigues da Silva, Evelyn Abreu De Amorim, Lucas Gonçalves Vilas et al.
A Ecopsicologia é uma abordagem integradora que busca conectar a sustentabilidade à saúde mental e emocional com a reconexão do ser humano à natureza. Ela parte da premissa de que o bem-estar humano está intrinsecamente ligado ao equilíbrio ambiental, estimulando práticas que promovam a sustentabilidade e o contato direto com a natureza. Plantar sua própria cannabis para fins terapêuticos se...
Cannabis is one of the most widely used psychoactive substances, with higher use rates in countries that have implemented policies to legalize medical or recreational use. Following the development of cannabis products with concentrations well above 10% THC (high potency, delta-9 tetrahydrocannabinol), the number of psychosis cases has also increased. Cannabis-attributable psychosis cases...
Posttraumatic stress disorder (PTSD) is characterized by difficulties in emotion regulation and altered recruitment of prefrontal control systems during cognitive reappraisal. Cannabinoid signaling has been implicated in stress and affect regulation, yet dose-dependent effects of acute delta-9-tetrahydrocannabinol (THC) on the neural mechanisms supporting reappraisal in PTSD remain unclear. In...
Since the discovery of the first antipsychotic, pharmacological treatment of schizophrenia (SCZ) has primarily relied on dopamine D2 receptor antagonist. However, variability in treatment responses highlights the need for novel biomarkers and therapeutics targets. Here, we developed a dual-hit mouse model combining maternal immune activation (MIA) induced by polyinosinic-polycytidylic acid...
CannabisJuly 15, 2026Saara Greene, Allyson Ion, Rochelle Maurice et al.
Objective: This paper presents rich and in-depth insights emerging from "Wading through the Weeds" (WttW), a participatory arts-based research study that used the Photovoice method to centre the lived experience of 23 mothers throughout Canada who consumed cannabis during pregnancy, lactation and motherhood. Method: Specifically, this paper examines and elucidates the ways that the mothers in...
Background: Cannabis use among adolescents with depression is prevalent. Dysfunction of the reward system has been implicated in each condition separately, yet rarely examined together. Here, we investigated resting-state properties of reward networks in an adolescent sample with diverse internalizing psychopathology and cannabis use patterns. Methods: Clinicians interviewed adolescents and...
Medicinal plants have been used in traditional medicine to alleviate a range of neurological and psychological disorders. Numerous plant-derived phytochemicals are known to modulate central nervous system activity by interacting with neurotransmitters, receptors, and neurochemical pathways. This review provides a comprehensive overview of medicinal plants with psychoactive properties, their...
Biological PsychologyJuly 9, 2026Nattanon Bunrodchu, Ekkasit Kumarnsit, Wan Khairunizam Wan Ahmad et al.
Long-term cannabis use can result in the development of cannabis use disorder (CUD) and dependence via the endocannabinoid system pathway. A brain network that has been consistently linked to various stages of addiction and various substances is the default mode network (DMN). By comparing EEG features between cannabis users and healthy participants, this study sought to identify EEG-based...