Sativex is a cannabis-plant extract delivering nearly 1:1 Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD) by oromucosal spray. It has been suggested that CBD attenuates THC-induced tachycardia, anxiety, and euphoria. In this study, pharmacodynamic effects were compared over 10.5 h in nine cannabis smokers randomly assigned to receive placebo, 5 and 15 mg oral synthetic THC, and low (5.4...
BACKGROUND: Approximately 20-40% of outpatients with diabetes experience elevated levels of emotional distress, varying from disease-specific distress to general symptoms of anxiety and depression. The patient's emotional well-being is related to other unfavorable outcomes, like reduced quality of life, sub-optimal self-care, impaired glycemic control, higher risk of complications, and...
Background Despite widely reported clinical and preclinical studies of rapid antidepressant actions of glutamate N-methyl-D-aspartic acid (NMDA) receptor antagonists, there has been very little work examining the effects of these drugs in stress models of depression that require chronic administration of antidepressants, or the molecular mechanisms that could account for the rapid responses....
본 연구는 만성우울증 재발방지를 위한 Segal, Williams와 Teasdale(2002/2006)의 MBCT 프로그램을 정서조절에 초점을 두어 수정보완한 정서조절 MBCT의 효과를 살펴본 것이다. 임상집단을 대상으로 정서조절곤란 및 부정적 정서와 관련된 인지양식, 우울, 불안에 대한 정서조절 MBCT의 효과를 확인하였다. 연구 결과, 약물치료와 MBCT를 병행한 참여집단(n = 9)은 약물치료만 받은 통제집단(n = 9)에 비해 마음챙김의 주의집중과 수용, 정서조절곤란, 인지회피, 반추적 반응, 우울, 불안, 에서 유의한 차이를 보여주었다. 참여집단의 사전과 사후의 변화에 대한 효과의 크기(d)를 분석한 결과, .72 - 1.51, 사전과 추수의 효과의 크기(d)는 .73 - 1.87이었으며,...
Mindfulness-based stress reduction (MBSR) is a structured 8-week group program teaching mindfulness meditation and mindful yoga exercises. MBSR aims to help participants develop nonjudgmental awareness of moment-to-moment experience. Fibromyalgia is a clinical syndrome with chronic pain, fatigue, and insomnia as major symptoms. Efficacy of MBSR for enhanced well-being of fibromyalgia patients...
Adenosine is an endogenous purine nucleoside that plays a neuromodulatory role in the central nervous system. A2a adenosine receptors have been involved in reward-related processes, inflammatory phenomena and neurotoxicity reactions. In the present study, we investigated the role of A2a adenosine receptors on the acute pharmacological effects, reinforcement and neuroinflammation induced by MDMA...
Journal of Clinical PsycologyJanuary 15, 2011Mohammad Narimani, Saeed Ariapooran, Abbas Abolghasemi et al.9 citations
Introduction: Poor mental health is one of the psychological problems in chemical weapon victims. This study aimed to compare the effectiveness of mindfulness and emotion regulation training on the mental health of chemical weapon victims. Method: An experimental design was conducted (pre-test, post-test and follow-up) with two experimental and one control groups. A sample of 47 chemical weapon...
PLoS One2011Jaymin Upadhyay, Scott J Baker, Prasant Chandran et al.
During wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. Non-human primate and human CNS imaging studies have identified the DMN in these two species. Clinical imaging studies have shown that the pattern of activity within the DMN is often modulated in various disease...
STUDY OBJECTIVES: The purpose of this study was to investigate whether insomnia symptoms and nightmares are related to suicidal ideation independent of one another and independent of the symptoms of anxiety, depression, and posttraumatic stress disorder (PTSD). DESIGN: The study consisted of questionnaires examining insomnia symptoms and nightmares, and symptoms of depression, anxiety, and...
ILAR Journal2011Divya Ramesh, Joel E Schlosburg, Jason M Wiebelhaus et al.
Marijuana (Cannabis sativa) is the most commonly used illicit drug worldwide as well as in the Unites States. Prolonged use of marijuana or repeated administration of its primary psychoactive constituent, Δ9-tetrahydrocannabinol (THC), can lead to physical dependence in humans and laboratory animals. The changes that occur with repeated cannabis use include alterations in behavioral,...