Brain and Cognition
April 1, 2012
Péter Simor, Péter Pajkossy, Klára Horváth et al.
Nightmare disorder is a prevalent parasomnia characterized by vivid and highly unpleasant dream experiences during night time sleep. The neural background of disturbed dreaming was proposed to be associated with impaired prefrontal and fronto-limbic functioning during REM sleep. We hypothesized that the impaired prefrontal and fronto-limbic functioning in subjects with frequent nightmares would...
The FASEB Journal
April 1, 2012
Evan J. Kyzar, Christopher Collins, Jeremy Green et al.
1 citation
Mescaline, phencyclidine (PCP) and psilocybin are potent hallucinogenic drugs strongly affecting both human and animal behavior. However, these compounds have not been previously investigated in zebrafish (Danio rerio), rapidly gaining popularity as a model in psychopharmacology research. Here, we examine the effects of mescaline, PCP and psilocybin in multiple behavioral paradigms. Mescaline...
Neuropsychiatric Disease and Treatment
March 14, 2012
Christina M Van der Feltz-Cornelis, Henk Biemans, Jan Timmer
Objective: Auditory hallucinations are generally considered to be a psychotic symptom. However, they do occur without other psychotic symptoms in a substantive number of cases in the general population and can cause a lot of individual distress because of the supposed association with schizophrenia. We describe a case of nonpsychotic auditory hallucinations occurring in the context of migraine....
Psychological Medicine
February 1, 2012
C. J. A. Morgan, Chelsea Gardener, G. Schafer et al.
Background Cannabis varies considerably in levels of its two major constituent cannabinoids – (delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Recently, we found evidence that those who smoked cannabis containing detectable levels of CBD had fewer psychotic-like symptoms than those whose cannabis had no CBD. The present study aimed, first, to replicate those findings and, second, to...
The Canadian Journal of Psychiatry
February 1, 2012
Walter E B Sipe, Stuart J. Eisendrath
283 citations
Mindfulness-based cognitive therapy (MBCT) incorporates elements of cognitive-behavioural therapy with mindfulness-based stress reduction into an 8-session group program. Initially conceived as an intervention for relapse prevention in people with recurrent depression, it has since been applied to various psychiatric conditions. Our paper aims to briefly describe MBCT and its putative...
Bioorganic & Medicinal Chemistry Letters
January 15, 2012
Cécile Béguin, Justin Potuzak, Wei Xu et al.
The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial agonists as pharmacological tools, we have modified 12-epi-salvinorin A, a compound which we have previously observed to be a KOPR partial agonist. Five...
Psychopharmacology
January 2012
Lena Wischhof, Michael Koch
Overactivation of serotonin (5-hydroxytryptamine, 5-HT)(2A) receptors causes impulsivity and attentional deficits. Since 5-HT(2A) receptors are known to entertain antagonistic interactions with metabotropic glutamate (mGlu)2/3 receptors, this interaction may provide an alternative target for a novel class of antipsychotics. The study characterizes interactions between 5-HT(2A) and mGlu2/3...
Breast cancer research and treatment
January 2012
Virginia P Henderson, Lynn Clemow, Ann O Massion et al.
The aim of this study was determine the effectiveness of a mindfulness-based stress-reduction (MBSR) program on quality of life (QOL) and psychosocial outcomes in women with early-stage breast cancer, using a three-arm randomized controlled clinical trial (RCT). This RCT consisting of 172 women, aged 20-65 with stage I or II breast cancer consisted of the 8-week MBSR, which was compared to a...
Journal of Neurology, Neurosurgery, and Psychiatry
January 2012
Jon Stone, Charles Warlow, Michael Sharpe
Functional weakness describes weakness which is inconsistent and incongruent with disease. It is also referred to as motor conversion disorder (DSM-IV), dissociative motor disorder (ICD-10) and 'psychogenic' paralysis. Studies of aetiology have focused on risk factors such as childhood adversity and life events; information on the nature and circumstance of symptom onset may shed light on the...
heiDOK (Heidelberg University)
2012
Victor Kai-Lam Cheung
11 citations
Even though the relationship between nightmare and dissociation is investigated in western populations with mental illness, relevant dream studies in non-patient Chinese population, and about specific type of nightmares, are completely lacking. According to continuity hypothesis of dreaming, nightmares reflect the negative emotion, mental conditions, and symptomatology of waking life. The...