Experiences of difficulty (e.g., anxiety, difficult emotions) can occur during mindfulness practice. This study characterized the occurrence of such difficulties, defined as abnormal distress, dysregulation or agitation, among high suicide risk participants during a mindfulness-based intervention. The study also evaluated whether mindfulness difficulties were associated with baseline...
Psilocybin, MDMA, and ketamine have emerged as potentially effective treatments for rapid amelioration of the symptoms of mood and related psychiatric disorders. All clinical data collected so far with regard to psilocybin or MDMA, which have reported positive outcomes for treating depression, anxiety, posttraumatic stress disorder, and drug or alcohol use disorders, have involved...
Psychedelic drugs including psilocybin, N,Nʹ-dimethyltryptamine (DMT) and lysergic acid diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various neuropsychiatric diseases, with a rapid onset of therapeutic activity. Notably, phase II trials have shown that psilocybin can produce statistically significant clinical effects following one or two administrations in...
Internet-based cognitive behavioral therapy (CBT) and stand-alone mindfulness meditation interventions are gaining empirical support for a wide variety of mental health conditions. In this study, we test the efficacy of web-based therapist-guided mindfulness-based cognitive behavioral therapy (CBT-M) for body dysmorphic disorder (BDD), a psychiatric disorder characterized by preoccupations with...
Editorial on the Research Topic Down the rabbit hole -the psychological and neural mechanisms of psychedelic compounds and their use in treating mental health and medical conditions Psychedelic substances have demonstrated promising therapeutic effects across a wide range of mental health conditions including depression (1-13) anxiety disorders including generalized anxiety (14-16) and social...
This research aims to determine the effectiveness of mindfulness-based cognitive therapy in reducing anxiety in cancer patients. The research method used is a systematic review, searching articles in six trusted databases: ProQuest, EBSCOhost, PubMed, Wiley Online Library, SpringerLink, and Google Scholar—article analysis using the PRISMA method. The research results show that mindfulness-based...
Postpartum depression (PPD) is a serious mental health problem that can negatively affect future generations. BDNF/AKT/mTOR signaling in the frontal lobe and hippocampus in mice is associated with depression, but its role in mice with PPD and their offspring is unknown. This study was aimed at investigating the effects of esketamine (ESK), a drug approved for treatment of refractory depression,...
Hallucinogens like lysergic acid diethylamide (LSD), psilocybin, and substituted N-benzyl phenylalkylamines are widely used recreationally with psilocybin being considered as a therapeutic for many neuropsychiatric disorders including depression, anxiety, and substance abuse. How psychedelics mediate their actions—both therapeutic and hallucinogenic—are not understood, although activation of...
Research SquareJune 7, 2024Målin Schmidt, Anne Hoffrichter, Mahnaz Davoudi et al.5 citations
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Abstract Psilocybin is studied as innovative medication in anxiety, substance abuse and treatment-resistant depression. Animal studies show that psychedelics promote neuronal plasticity by strengthening synaptic responses and protein synthesis. However, the exact molecular and cellular changes induced by psilocybin in the human brain are not known. Here, we treated human cortical neurons...
The present study aimed to assess focus/concentration, perception of quality of life, class attention, and anxiety, as well as class attendance and academic performance of nursing undergraduates from a Higher Education Institution before and after the application of breathing and mindfulness meditation techniques. Forty-five seventh-semester (fourth-year) students of both genders, aged 18 and...