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Anxiety: all studies

Page 484 of 773: studies 4,831 to 4,840 of 7,721, newest first. Back to the anxiety overview

Research

Exploring the interplay of chronic toxoplasmosis and NMDAR dysfunction: Insights into schizophrenia-like behaviors and therapeutic potential.

Open veterinary journal July 1, 2024 Seyedeh Mina Masoumi, Mohammad Reza Youssefi, Seyed Shapoor Reza Shojaei 2 citations

Chronic toxoplasmosis has been strongly implicated in the development of psychosis and schizophrenia. Additionally, the understanding of schizophrenia has been significantly reshaped by insights into N-methyl-D-aspartate receptor (NMDAR) hypofunction. This study aimed to compare the behavioral, antioxidant, and NMDAR changes in mice subjected to Toxoplasma gondii infection and those treated...

DOI: 10.5455/OVJ.2024.v14.i7.13 (opens in new tab) Full text (opens in new tab) Ketamine Antioxidant status Behavioral alterations Toxoplasma gondii +4

Extended-release ketamine tablets for treatment-resistant depression: a randomized placebo-controlled phase 2 trial.

Nature Medicine July 1, 2024 Paul Glue, Colleen Loo, Johnson Fam et al. 60 citations

Ketamine has rapid-onset antidepressant activity in patients with treatment-resistant major depression (TRD). The safety and tolerability of racemic ketamine may be improved if given orally, as an extended-release tablet (R-107), compared with other routes of administration. In this phase 2 multicenter clinical trial, male and female adult patients with TRD and Montgomery-Asberg Depression...

Neiskorišteni farmakološki potencijal gljive muhare - Amanita muscaria (L.) Lam. (1783)

Glasilo Future June 30, 2024 Domagoj Šmidt, Ivan Širić 1 citation

Amanita muscaria (L.) Lam., gljiva poznatija pod narodnim imenom crvena muhara stigmatizirana je kao otrovna gljiva u većini znanstvene literature i javnom mišljenju. Danas postoje brojni povijesni zapisi i anegdote o pozitivnim zdravstvenim učincima vrste A. muscaria, kao što su smanjenje tjeskobe, bolova, upala i ublažavanja kroničnih neurodegenerativnih poteškoća poput Parkinsonove i...

Unlocking the Therapeutic Potential of DMT’s: Molecular Modelling Insights into Nueropharmacological Mechanisms and Clinical Prospects

Letters in Applied NanoBioScience June 30, 2024 Rishabh Khare, K. Rajagopal, Srikanth Jupudi et al.

Depression is a critical mental ailment as it impacts about 5% of the global population, prompting scientists to create more efficacious antidepressants. The monoamine-deficiency hypothesis suggests that depression is caused by the depletion of certain neurotransmitters like serotonin, norepinephrine, and dopamine in the brain, where serotonin plays the most critical role among all and has been...

PS06 Mindfulness-based stress reduction alleviates flushing and negative emotions in rosacea: an exploratory study

British Journal of Dermatology June 28, 2024 Deyu Song, Xian Jiang

Abstract Rosacea is commonly associated with a significant psychosocial burden. Mindfulness-based stress reduction (MBSR) has shown promising prospects in inflammatory skin diseases, including psoriasis and atopic dermatitis (Kishimoto S, Watanabe N, Yamamoto Y et al. Efficacy of integrated online mindfulness and self-compassion training for adults with atopic dermatitis: a randomized clinical...

Examining the Role of Oxytocinergic Signaling and Neuroinflammatory Markers in the Therapeutic Effects of MDMA in a Rat Model for PTSD.

Pharmaceuticals June 27, 2024 Haron Avgana, Roni Shira Toledano, Irit Akirav 8 citations

MDMA-assisted psychotherapy has shown potential as an effective treatment for post-traumatic stress disorder (PTSD). Preclinical studies involving rodents have demonstrated that MDMA can facilitate the extinction of fear memories. It has been noted that MDMA impacts oxytocin neurons and pro-inflammatory cytokines. Thus, the aim of this study was to explore the role of oxytocinergic signaling...

The roles of intolerance of uncertainty and mindfulness in psychological distress: a two-wave longitudinal study

Current Psychology June 26, 2024 Ayşe Altan‐Atalay, Amal Abdulcebbar, Laçin Kantarcı et al. 5 citations

Abstract Intolerance of uncertainty (IU) is a vulnerability factor that is believed to play a significant role in the development and maintenance of many affective disorders. Previous research indicated that the strength of the association between IU and psychological distress tend to change depending on certain trait characteristics. Therefore, the current study aimed to examine whether the...

Effectiveness of Web-Based Mindfulness-Based Interventions for Patients With Cancer: Systematic Review and Meta-Analyses.

Journal of Medical Internet Research June 25, 2024 Ting Wang, Chulei Tang, Xiaoman Jiang et al. 15 citations

Cancer has emerged as a considerable global health concern, contributing substantially to both morbidity and mortality. Recognizing the urgent need to enhance the overall well-being and quality of life (QOL) of cancer patients, a growing number of researchers have started using online mindfulness-based interventions (MBIs) in oncology. However, the effectiveness and optimal implementation...

DOI: 10.2196/47704 (opens in new tab) Full text (opens in new tab) Adherence Cancer Delivery mode Efficacy +10

The impact of narcolepsy symptoms and treatment on sex life - current evidence and reports

Current Problems of Psychiatry June 24, 2024 Karol Kasprzak, Agnieszka Dyzma-Kasprzak, Z. Wingralek et al.

Introduction: Narcolepsy (NT) can manifest as excessive daytime sleepiness (EDS), cataplexy, hypnagogic (HHG) and hypnopompic (HHP) hallucinations, sleep paralysis, orgasmolepsy – all of which may affect patients' functioning. The aim of the study was to determine the impact of NT, specific sexual dysfunctions and drugs used in NT on sex life. Materials and methods: A narrative review was...

Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?

Frontiers in Human Neuroscience June 19, 2024 Giuseppe Pasculli, Pierpaolo Busan, Eric S. Jackson et al. 5 citations

Developmental stuttering (DS) is a neurodevelopmental speech-motor disorder characterized by symptoms such as blocks, repetitions, and prolongations. Persistent DS often has a significant negative impact on quality of life, and interventions for it have limited efficacy. Herein, we briefly review existing research on the neurophysiological underpinnings of DS -specifically, brain metabolic and...