The classical psychedelics (+)-lysergic acid diethylamide (LSD), psilocybin, and mescaline exert their psychedelic effects via activation of the 5-HT2A serotonin receptor (5-HT2AR). Recent clinical studies have suggested that classical psychedelics may additionally have therapeutic potential for many neuropsychiatric conditions including depression, anxiety, migraine and cluster headaches, drug...
Depression affects hundreds of millions globally, and in 2019, esketamine, an S-enantiomer of ketamine, was approved for treatment-resistant depression (TRD). While effective, esketamine carries risks, including abuse potential and adverse effects even at low doses. As a result, ketamine's metabolite, (2R,6R)-hydroxynorketamine ((2R,6R)-HNK), has garnered attention for its potential...
To examine the mechanistic role of cognitive flexibility in mindfulness intervention for emotional distress (MIED), we conducted two randomized controlled trials. In Study 1, 607 participants experiencing high emotional distress were randomly assigned to either an MIED program group (N = 304) or a waitlist control group (N = 303). Levels of cognitive flexibility, anxiety, depression, and...
Many patients with inflammatory bowel disease (IBD) suffer from psychological distress, sleep disturbances, fatigue, and a reduced quality of life-even during remission. Mindfulness-Based Cognitive Therapy (MBCT) has been effective in other populations, and therefore it may also benefit IBD patients. The primary objective was to evaluate the effectiveness of MBCT plus treatment as usual (TAU)...
Mindful Sport Performance Enhancement (MSPE) is a manualized mindfulness-based intervention for performers. The availability and adaptability of MSPE make it accessible for application and research. There has been a proliferation of research examining the effects of MSPE with performers since it's development in 2009. However, there have been no attempts to synthesize the extant literature....
EJNMMI ResearchJuly 11, 2025Chun-Qing Zhou, Xueying Wang, Mei-Chao Men et al.
This study delineates brain metabolic signatures underlying neuroendocrine-psychosocial interactions in Kallmann syndrome (KS), a rare genetic disorder characterized by congenital hypogonadism and anosmia. In this prospective case-control study, 30 KS patients and 30 matched healthy controls (HCs) underwent brain [18F]FDG PET scans, sex hormone assays, and standardized neuropsychological...
This study evaluated the effects of Mindfulness-based stress reduction(MBSR) and cognitive behavioural stress reduction(CBSR) on depression, anxiety, and perceived stress in medical students. A total of 323 medical students studying in Ankara, Turkey, applied to participate and were assessed using the Mini International Neuropsychiatric Interview. Medical students with a psychotic disorder,...
Mindfulness-based interventions (MBIs) have been previously linked with improved cognition and reduced stress, anxiety, and depression. Yet, traditional MBIs are lengthy and resource intensive. Brief and online MBIs represent a bridge into more extensive practice—but questions of whether these protocols improve cognition and affect remain. The present experiment used a randomized longitudinal...
Clinical ToxicologyJuly 8, 2025Margot Balcaen, Nik De Brabanter, Nick Verougstraete et al.1 citation
Synthetic cathinones, known as 'gravel' or 'bath salts', include α-pyrrolidinoisohexiophenone and its analogues α-pyrrolidinovalerophenone and α-pyrrolidinohexanophenone; often referred to as 'flakka' on the street or 'zombie drug' in media reports. Documented motivation for use includes libido enhancement and appetite suppression. Since its international scheduling,...
We aimed to investigate the relationship between changes in resting-state functional connectivity in a subregion of the hippocampus and the antidepressant effects of esketamine as well as to identify potential neuroimaging markers of the treatment outcomes. Twenty-nine patients with major depressive disorder (MDD) received six intravenous infusions of esketamine. All patients completed the...