The Journal of Clinical Pharmacology
June 1, 2026
Paul Glue, Ben Beaglehole
Ketamine is a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) glutamate receptor. It was approved by the US Food and Drug Administration for anesthesia in 1970. The only other related US regulatory approval since then has been for esketamine nasal spray for depression in 2019. Over this time ketamine has been repurposed by mainly academic researchers, reporting clinical activity...
Cureus
June 1, 2026
Hoi Ki Cheung, Ngo Cheung
A proportion of patients with obsessive-compulsive disorder (OCD) continue to experience disabling symptoms despite standard serotonergic treatment, antipsychotic augmentation, and psychological input. Contamination-focused OCD can be especially persistent when rituals are embedded in the home environment and reinforced by family patterns. Recent work has drawn attention to glutamatergic...
Psychedelic Medicine
June 1, 2026
Manal Muteb Alanazi, Mohammed M Alqahtani
The neuropsychological effects of psychedelic compounds are well-documented; however, their respiratory activity is less clear. Since respiration is a physiologically significant process and psychedelics have increasingly attracted attention in therapies, assessing the potential effects on respiration is relevant. The present narrative literature review compiled evidence on serotonergic...
Complementary Therapies in Medicine
June 1, 2026
Moirangthem Joychand Singh, Sunil Singh Yadav, Sangeeth Somanadhapai et al.
Epilepsy is a chronic neurological disorder characterized by altered cortical excitability. The disorder is often associated with psychological distress and reduced quality of life. The purpose of the present review is to critically summarize the evidence on the effectiveness of meditation-based interventions for people with epilepsy. A comprehensive search was conducted in PubMed, Scopus, and...
Journal of Psychopharmacology
June 1, 2026
Gabrielle Smith, Timothy Piatkowski, Jason Ferris et al.
1 citation
While research on novel therapeutic applications of ketamine is expanding, particularly in controlled settings, there is limited exploration of its consumption related to self-treatment of psychiatric conditions. This study investigated the characteristics of people who use ketamine and psychedelics for self-treatment of psychiatric conditions, providing insight into patterns of use within this...
The Journal of Sexual Medicine
June 1, 2026
M Almada, R Neto, A Pinto et al.
Abstract Introduction Emerging in the late 1990s within sexualized contexts, chemsex-the intentional use of psychoactive substances to enhance or prolong sexual activity-has evolved from a niche practice to a globally recognized public health concern, particularly among LGBTQ populations and men who have sex with men (MSM). Early accounts involved 3,4-methylenedioxymethamphetamine (MDMA) and...
Drug and Alcohol Dependence Reports
June 1, 2026
Christopher Medina-Kirchner, Scott E Lukas
Ecstasy is commonly used on weekends and linked to post-use mood declines. Laboratory studies with pure MDMA rarely detect residual effects, whereas naturalistic studies more often report mood reductions. The timing and contextual drivers of these effects remain unclear. Data from seventeen participants reporting weekend ecstasy use (10 male, 7 female; 19-38 years) were drawn from a previously...
Psychedelic Medicine
June 1, 2026
Sara N Lappan, Sean D Davis
Psychedelic-assisted psychotherapy has demonstrated efficacy in treating individual mental health conditions such as addiction, anxiety, depression, and post-traumatic stress disorder. However, current research predominantly focuses on individual experiences, overlooking the relational and systemic factors that influence healing and long-term therapeutic outcomes. This conceptual article...
Psychodynamic psychiatry
June 1, 2026
Christopher W. T. Miller, Zofia Kozak
There has been an increasing interest in the use of classic psychedelics (such as psilocybin) and 3,4-methylenedioxymethamphetamine (MDMA) for treating mental health conditions. Individuals often describe psychedelic sessions as among the most significant experiences in their lives, emphasizing the sense of awe, connectedness, and spiritual transformation taking place. While the psychedelic...
Journal of Telenursing
May 31, 2026
Aisyah Salsabila Nur’Azizah, Wita Oktaviana, Pudji Lestari
This study aimed to determine the effectiveness of mindfulness through yoga on the quality of life of patients with hallucinations. The study used a case study design with a one-group pretest-posttest approach. The results showed that before the intervention, respondents' quality of life was in the poor to moderate category, with scores ranging from 26–58. After the intervention, all...