Cureus
May 27, 2022
Robert Sotille, Herpreet Singh, Anne Weisman et al.
2 citations
Current medications have not been effective in reducing the prevalence of mental illness worldwide. The prevalence of illnesses such as treatment-resistant depression has increased despite the widespread use of a broad set of psychopharmaceuticals. Transcranial magnetic stimulation and ketamine therapy are making great strides in improving treatment-resistant depression outcomes but they have...
Frontiers in Psychiatry
May 23, 2022
Raquel Bennett, Christian Yavorsky, Gary Bravo
12 citations
Bipolar disorder (type 1) is a serious and chronic psychiatric illness that can be difficult to treat. Many bipolar patients have refractory depressive episodes. Racemic ketamine, a glutamate modulator with prominent dissociate and psychedelic properties, has been demonstrated to have rapid acting antidepressant and anti-obsessional effects which may be useful for treating the symptoms of...
Cureus
May 23, 2022
Kawther N Elsouri, Sahand Kalhori, Diego Colunge et al.
15 citations
Post-traumatic stress disorder (PTSD) is an anxiety disorder that often presents after exposure to a traumatic, life-threatening event. Experiencing a traumatic event is not rare, with inciting incidents ranging from being burglarized to politically motivated genocide. While traditional psychopharmacology and psychotherapy are the mainstays of the treatment of PTSD currently, psychoactive drugs...
Pharmaceuticals
May 23, 2022
Danish Mahmood, Sattam Khulaif Alenezi, Md Jamir Anwar et al.
29 citations
Psychedelics such as lysergic acid diethylamide (LSD), psilocybin (magic mushrooms), and mescaline exhibit intense effects on the human brain and behaviour. In recent years, there has been a surge in studies investigating these drugs because clinical studies have shown that these once banned drugs are well tolerated and efficacious in medically supervised low doses called microdosing....
International Journal of Environmental Research and Public Health
May 13, 2022
Shadi Beshai, Sandeep Mishra, Justin R Feeney et al.
Public safety personnel (PSP) face frequent stressors that increase their risk of developing symptoms of depression and anxiety. In addition to being exposed to potentially traumatic events, PSP trainees may face a compounded risk of developing mental health symptoms, as their training environments are conducive to social comparisons and the resultant painful emotion of envy. Envy is associated...
May 3, 2022
Ceci Westbrook, Janine M. Dutcher, Susan Kusmierski et al.
preprint
Uncontrollable worry is a hallmark of generalized anxiety disorder and a transdiagnostic feature of psychopathology. Mindfulness-based strategies show promise for treating worry, but neural mechanisms of mindful disengagement remain incompletely characterized. We recruited 40 participants with clinically significant worry to undergo fMRI while engaging in real-time, idiographic worry and...
Open heart
May 2022
Tarun Kumar Mittal, Emma Evans, Alison Pottle et al.
The study evaluated the feasibility of mindfulness-based cognitive therapy (MBCT) in patients with non-cardiac chest pain by assessing their willingness to participate and adhere to the programme, and for these data to help further refine the content of MBCT for chest pain. This prospective 2:1 randomised controlled trial compared the intervention of adapted MBCT as an addition to usual care...
Indian Journal of Psychiatry
May 1, 2022
Paul Alan Arkin Alvarado-García, Marilú Roxana Soto-Vásquez, Luis Enrique Rosales-Cerquín
Background: As the COVID-19 pandemic progresses, mental health begins to be affected. In this sense, practical and low-cost solutions are necessary to minimize the impact on the population. Aim: This study aimed to determine the effect of a mindfulness-based online intervention for mental health during times of COVID-19. Method: A quasi-experimental study was carried out with pre-test and...
Case Reports in Psychiatry
April 26, 2022
Jeremy Weleff, Kelly A. Bryant, Alexsandra Kovacevich et al.
5 citations
Background. Clinical trials have demonstrated that subanesthetic intravenous ketamine exerts antidepressant effects lasting a week or longer postinfusion, as well as antisuicidal effects starting approximately 4 hours postinfusion and lasting 72 hours or longer. These findings have generated considerable enthusiasm within psychiatry. However, reports of treatment-emergent suicide attempts and...
Substance Use & Misuse
April 25, 2022
Dimitri Daldegan-Bueno, Dóra Révész, Paulo Rogério Morais et al.
15 citations
Background: Preliminary evidence suggests that long-term ayahuasca use is associated with better psychosocial outcomes and less drug use; however, available data on the association between ayahuasca intake frequency and psychosocial outcomes is limited. Objectives: We sought to characterize and investigate the association of regular ayahuasca use, as compared to non-regular use, on licit...