BACKGROUND: -dimethyltryptamine (DMT); however, long-term effects, including broader well-being dimensions, are sparsely explored across populations. AIMS: Investigating whether DMT produces sustained improvements in anxiety, life satisfaction, and quality of life, in both healthy individuals and patients with treatment-resistant depression (TRD). METHODS: In 2 open-label clinical trials, 27...
This exploratory single-group pilot study examined whether a brief mindfulness-meditation routine was associated with lower Foreign Language Anxiety (FLA) and improved language-learning experience among Indonesian ESL learners in Singapore. Through a mixed-methods action research design, the study conducted twelve face-to-face mindfulness sessions across four weeks with young learners who...
In this paper, we propose a trans-materialist information-theoretical approach to a full spectrum of conscious experience, from its normative embodied mode as part of an integrated brain/mind system to altered modes of consciousness, including nonlocal and near-death experiences (NDE). It allows for bridging the Cartesian gap and resolving the “hard problem” of non-material mind arising from...
Anxiety is one of the most prevalent mental health problems in adolescence, and its onset often coincides with the secondary school years. Mindfulness-based interventions (MBIs) have shown short-term benefits for reducing anxiety in young people, but the durability of these benefits after treatment remains uncertain. To inform clinical and school-based practice, a quantitative synthesis focused...
High Resolution Image Download MS PowerPoint Slide Provided herein are novel 6,5-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse, and headaches, and processes for preparing such compounds.
The fear of death (death anxiety) is a risk factor for various mental health conditions. Death anxiety has been theorized to elicit physiological arousal and worry and is empirically associated with attachment insecurity, each of which has been linked to disrupted sleep. However, limited research has explored the relationship between death anxiety, nightmares and insomnia. We examined the...
Introduction: Meditation has shown benefits for mental health, yet difficulties may appear when practicing autonomously, particularly in people prone to anxiety or low self-esteem. The POEBRA (Program for Optimizing Self-Esteem and Benevolence and Reducing Anxiety) was developed to facilitate meditation learning through a structured, embodied, guided approach based on Full-Presence meditation....
Depersonalization/derealization (dpdr) is known to occur across mood and anxiety disorders (MAD) and has been proposed as a marker of worse illness. However, despite the well-known clinical association, there are no epidemiological data on the relationship between dpdr and MAD. In this NCS-R analysis clinically significant dpdr (DPDR-C) was defined as "sometimes" or "often" past-month...
Temporal interference (TI) electrical stimulation is a novel neuromodulation method that can target deep brain structures to enhance the impact of behavioral techniques. We tested the feasibility of TI targeting the ventral striatum (VS) during an emotion regulation practice (breath-focused mindfulness meditation). To assess target engagement, we used electroencephalography (EEG) to measure...
The elderly population in Indonesia has a high prevalence of hypertension reaching 63.2%. This physical condition is exacerbated by anxiety reaching 45-60% in hypertensive elderly people in nursing homes who have not received comprehensive non-pharmacological interventions. This activity aims to empower the elderly in managing anxiety through the application of a combination of Mindfulness...