Psilocybin and 3,4-methylenedioxymethamphetamine (MDMA) produce rapid, enduring therapeutic effects in post-traumatic stress disorder (PTSD); however, the underlying cellular mechanisms remain incompletely understood. This study investigated whether adult myelin plasticity contributes to the therapeutic actions of psilocybin and MDMA in a rat model of contextual fear conditioning. Adult male...
Psychedelics, particularly psilocybin, have shown therapeutic potential across several psychiatric conditions, including depression, anxiety, obsessive-compulsive disorder, and anorexia nervosa (AN). These disorders often share social deficits that may be effectively alleviated by psychedelics considering their use has been linked with emotional empathy and enhanced social cognition. However,...
Individu dewasa awal biasanya mulai memperhatikan masalah kesehatan karena mulai rentan terhadap penyakit kronis dan penyakit mental, terutama seiring bertambahnya sumber informasi kesehatan yang beredar, hal ini menyebabkan beberapa orang mempercayai informasi kesehatan yang beredar dan meyakini bahwa dirinya sedang mengalami masalah kesehatan, sehingga menyebabkan munculnya health anxiety. Di...
PROMOTORFebruary 2, 2026Ni Made Saithanya Gitanjali Dhevi, Rofi Bramantyo, Septy Rianty Salsabilla Dwi Putri et al.
Depression is a psychological disorder that affects aspects of affection, physiology, cognition, and individual behavior, and has an impact on significant changes in daily life. Data from the Ministry of Health of the Republic of Indonesia (2023) shows a national prevalence of depression of 1.4%, with the age group of 15-24 years recording the highest rate of 2%. One approach that is considered...
Classic serotonergic psychedelics such as LSD and psilocybin show promising antidepressant effects in controlled trials, but real-world data from routine clinical care remain limited. This study retrospectively analysed routine data from adults with treatment-resistant depressive and/or anxiety disorders who received a first standardized Psychedelic-assisted Psychotherapy (PAP) cycle with 100...
Background: Mindfulness-based interventions (MBIs) have demonstrated consistent efficacy in reducing anxiety and depression. However, the underlying psychological mechanisms explaining these effects particularly emotional regulation and resilience remain underexplored in Indian clinical populations. Objective: This study investigates the mediating roles of emotional regulation and resilience in...
Ketamine, a nonselective NMDA-receptor antagonist, is an emerging therapeutic for treatment-resistant depression and could also be a promising treatment for anxiety and post-traumatic stress disorders. However, preclinical studies in these areas lack methodological standardization, limiting clinical translatability. This review evaluates ketamine's anxiolytic potential in rodents by examining...
Background: Anxiety and depression are leading causes of disability in India, with nearly 15% of adults experiencing some form of mental morbidity. Despite existing pharmacological and psychotherapeutic treatments, accessibility, affordability, and cultural barriers persist. Mindfulness-Based Interventions (MBIs), adapted from the Mindfulness-Based Stress Reduction (MBSR) model, offer a...
Background: Cardiovascular disease remains a leading global health burden, with Coronary Heart Disease (CHD) accounting for nearly half of cases. Cardiac catheterization, widely performed in Indonesia, is vital for diagnosis and treatment but often provokes significant anxiety, potentially affecting hemodynamic stability. Mindfulness-based interventions have shown effectiveness in reducing...
Abstract Background In recent years, mental health problems among middle school students have shown a trend of younger age and diversification. Difficulty in emotional regulation has become a core factor affecting their academic performance and social adaptation. The research takes the improvement of middle school students’ emotional management ability as the core goal, proposes an intervention...
Amidst the growing prevalence of anxiety disorders and the limitations of existing treatments, there is a need to expand treatment options beyond conventional therapy and medication. The popularity of breathwork has grown enormously, but it is still in the process of creating a robust body of evidence to validate its utility. This research employs a true-experimental design to compare pretest...
The global mental health crisis has escalated to unprecedented levels, with stress, anxiety, and depression posing major public health concerns. Conventional interventions have shown limited success in addressing these multifaceted issues, prompting researchers to explore alternative solutions. Yoga Nidra (YN), a meditative practice, has gained momentum over the past decade as a potential...
Background: The effectiveness of meditation for anxiety management is well-documented; however, the role of adherence and its impact on physiological recovery remains underexplored. Objective: This study investigates the association between meditation adherence, anxiety reduction, and physiological outcomes (heart rate and blood pressure) in adults diagnosed with generalized anxiety disorder...
Background: Anxiety disorders are among the most prevalent mental health conditions globally. Non-pharmacological therapies such as meditation are gaining recognition as effective adjuncts to standard treatment. Objective: To examine the effectiveness of an 8-week structured meditation programme in reducing anxiety symptoms and enhancing psychological well-being among adults diagnosed with...
INDOGENIUSFebruary 1, 2026Bachtiar Safrudin, Dwi Widyastuti, Agil Anata et al.
Background & Objective: Older adults often experience psychological and physiological changes that lead to stress and sleep disorders such as insomnia. Mindfulness and meditation therapy have been widely applied as non-pharmacological interventions to improve sleep quality and reduce anxiety among elderly populations. This literature review aims to analyze and synthesize evidence from...
Spiritual interventions, including meditation, prayer, mindfulness, and compassionate care, have gained increasing attention for their potential to enhance both psychological resilience and overall health. This systematic review and meta-analysis examined eight eligible studies conducted across the USA, Europe, and China to assess the impact of such interventions on key outcomes, namely anxiety...
The neurotic disorders (e.g., depression, dysthymia, generalized anxiety disorder, panic disorder, agoraphobia, social anxiety, post-traumatic stress disorder, and obsessive-compulsive disorder) are costly and difficult to treat. Diagnosis is based on symptoms not biological causes. Here, we summarize New Zealand-based work developing EEG biomarkers and novel treatments. Working at the...
Introduction: Comorbid conditions such as major depressive disorder, anxiety disorders, and posttraumatic stress disorder are common among Veterans, and the presence of multiple conditions requires innovative treatment approaches. The Newly Institute in Calgary, Alberta, Canada, has introduced a novel intervention combining sublingual ketamine therapy with a medically managed transdiagnostic...
Second-generation mindfulness-based interventions (SG-MBIs), which integrate ethical and moral practices, have emerged as promising treatments for depressive and anxiety symptoms. This meta-analysis aims to evaluate the effectiveness of SG-MBIs in reducing depression and anxiety among adults. We conducted a meta-analysis of randomized controlled trials (RCTs) including adults from clinical...
Brain and BehaviorFebruary 1, 2026Burçin Ün, Zeki Akarsakarya, Özlem Yorulmaz Özü et al.
Previous studies have suggested that adenosinergic system in the central nervous system may play a role in both behavioral changes and the physiopathology induced by Δ9-tetrahydrocannabinol (THC), and this is thought to be mediated by adenosine A2A receptors (A2ARs). However, the contribution of the adenosinergic system to the anxiety-like behaviors in response to THC in mice is not well...