Back to table of contents Previous article Next article Full AccessPsychedelic Medicine: Much More Study NeededStanley CaroffM.D.Stanley CaroffSearch for more papers by this authorM.D.Published Online:30 Apr 2019https://doi.org/10.1176/appi.pn.2019.5a24AbstractStanley Caroff, M.D., is a professor of psychiatry at the University of Pennsylvania Perelman School of Medicine.While new-age spiritual...
Simulation training is an effective teaching tool enabling learners to gain a subjective understanding of a range of skills. Our aim in this study was to pilot and evaluate a newly designed simulation of auditory hallucinations as a future training tool for clinicians. This was a mixed-methods study in two parts. In Phase 1, trainee and qualified clinical psychologists (N = 25) attended the...
Abstract: The act of listening to music to reach altered states of consciousness is common across many different cultures around the world, ranging from tribal settings in Central Java, Indonesia, to EDM (electronic dance music) dance clubs in the Western world. Despite the widespread listenership to trance music, we lack a comprehensive, scientific account of how features of the musical...
This paper examines the relationship between the E. Husserl’s theory of noema and N. L. Muskhelishivili’s and Yu. A. Schreider’s concept of the organising image (image-sprout) which was proposed in the paper “Meaning of Text as an Inner Image”. The purpose of this study is to demonstrate isomorphism of these two concepts. It can serve as a methodological and ideological basis for combining...
Ketamine is a unique drug that has psychedelic and anesthetic properties in a dose-dependent manner. Recent studies have shown that ketamine anesthesia appears to maintain the spatiotemporal complexity of cortical activation evoked by transcranial magnetic stimulation, while a psychedelic dose of ketamine is associated with increased spontaneous magnetoencephalographic signal diversity....
One of the main limitations of pharmacological fMRI is its inability to provide a molecular insight into the main effect of compounds, leaving an open question about the relationship between drug effects and haemodynamic response. The aim of this study is to investigate the acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on functional connectivity (FC) using a novel multimodal method...
Sounds can modulate activity in visual cortex, facilitating the detection of visual targets. However, these sound-driven modulations are not thought to evoke conscious visual percepts in the general population. In individuals with synesthesia, however, multisensory interactions do lead to qualitatively different experiences such as sounds evoking flashes of light. Why, if multisensory...
Penrose and Hameroff assert that brain computations, including quantum computations, involving hydrophobic areas of microtubules whose electron clouds go into orchestrated superpositions and reductions that lead to proto-conscious elements, or "bings" that become orchestrated into conscious experiences. Their assertion, however, like the findings of the neural correlates of consciousness, does...
Modern sophisticated archeometric instruments are increasingly capable of detecting the presence of psychoactive plant sources in archeological contexts, testifying the antiquity of humanity’s search for altered states of consciousness. The purpose of this article is to provide a general picture of these findings, covering the main psychoactive plant sources of the world, and identifying the...
The neuronal connectivity patterns that differentiate consciousness from unconsciousness remain unclear. Previous studies have demonstrated that effective connectivity, as assessed by transcranial magnetic stimulation combined with electroencephalography (TMS-EEG), breaks down during the loss of consciousness. This study investigated changes in EEG connectivity associated with consciousness...