In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid receptor activation. Cannabis has been historically used to relieve some of...
Parmi les substances hallucinogènes, les dérivés ergotés occupent une place non négligeable. Différents champignons ou plantes en renferment. Le plus connu est l'ergot de seigle, un sclérote parasite du seigle. Dans les cas d'intoxications par des céréales contaminées les victimes ont présenté de nombreux troubles dont des hallucinations, mais il n'a pas été décrit de cas d'individus consommant...
What is the relation between visual attention and visual awareness? It is difficult to imagine being aware of something without attending to it, and by some, visual consciousness is simply equated to what is in the focus of attention. However, findings from psychological as well as from neurophysiological experiments argue strongly against equating attention and visual consciousness. From these...
Meditation is a specific consciousness state in which deep relaxation and increased internalized attention coexist. There have been various neurophysiological studies on meditation. However, the personal predispositions/traits that characterize the properties of meditation have not been adequately studied. We analyzed changes in neurophysiological parameters [EEG coherence and autonomic nervous...
<i>Ayahuasca,</i> a South American psychotropic plant tea obtained from <i>Banisteriopsis caapi</i> and <i>Psychotria viridis</i>, combines monoamine oxidase-inhibiting β-carboline alkaloids with N,N-dimethyltryptamine (DMT), a psychedelic agent showing 5-HT<sub>2A</sub> agonist activity. In a clinical research setting, <i>ayahuasca</i> has demonstrated a combined stimulatory and psychedelic...
Ibogaine is a tremorigenic hallucinogen that has been proposed for clinical use in treating addiction. We previously reported that ibogaine, administered systemically, produces degeneration of a subset of Purkinje cells in the cerebellum, primarily within the vermis. Ablation of the inferior olive affords protection against ibogaine-induced neurotoxicity leading to the interpretation that...
A conceptual replication of the Hall-experiment to test the 'subjective reduction' interpretation of the measurement problem in Quantum Physics is reported. Two improvements are introduced. First the delay between pre-observation and final observation of the same quantum event is increased from a few microseconds in the original experiment to 1 second in this replication. Second, rather than...
Objetivo: recopilar y analizar la información sobre los efectos de la MDMA obtenida en estudios controlados en humanos. Método: la mayoría de ensayos analizados han sido de diseño enmascarado a doble ciego, cruzados, con asignación aleatoria a la secuencia de tratamientos, y controlados con placebo y/o fármaco patrón. Resultados: además del incremento de la presión y frecuencia cardíaca, la...
Objetivo: realizar una revisión del LSD y otros alucinógenos desde un punto de vista histórico-cultural, farmacológico y de consecuencias clínicas, especialmente psiquiátricas. Resultados: datos aportados por el PNSD ponen de manifiesto que más del 2% de la población española reconoce haber consumido esta sustancia, que ejerce su acción a través de los sistemas de neurotransmisión...
Addiction BiologyDecember 1, 2003Nahal Ketabi‐Kiyanvash, Johanna Weiss, Walter Emil Haefeli et al.
Abstract: There are increasing numbers of deaths related to taking MDMA, MDE and PMA reported where the deceased typically took several different drugs with these compounds. Hence, mutual modulation of the pharmacokinetics in drug combinations with “ecstasy” might be a risk factor for “ecstasy”‐related morbidity. Regarding potential drug‐drug interactions, there are no data evaluating a...