Clinical Toxicology
August 2010
Donna Seger
This article reviews the role and clinical importance of specific neuroadaptations that may occur following use of cocaine, metamfetamine, and 3,4,methylenedioxymetamfetamine (MDMA). A literature search was performed using OVID MEDLINE and PubMed for all years to the present date, which identified 250 papers of which 154 were considered relevant. MECHANISMS OF ACTION OF COCAINE AND...
August 1, 2010
Ryan D. Foster
The researcher examined the effectiveness of a near-death experience (NDE) learning module on reducing distressing aspects and enhancing a growth aspect of grief among bereaved adults. Participants were 22 females and 2 males; 2 identified as African American, 3 as Asian, 2 as Latina/o, and 17 as White; aged 20 to 71 years with mean age 35.3 years. In this experimental design, the researcher...
The International Journal of Neuropsychopharmacology
August 1, 2010
Nicolas Tournier, Lucie Chevillard, Bruno Mégarbane et al.
122 citations
Drug interaction with P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) may influence its tissue disposition including blood-brain barrier transport and result in potent drug-drug interactions. The limited data obtained using in-vitro models indicate that methadone, buprenorphine, and cannabinoids may interact with human P-gp; but almost nothing is known about drugs of abuse and...
Analysis
July 30, 2010
John Preston
Robert Rupert’s book is a thorough examination of a family of views of cognition that have emerged from recent work in what is sometimes called ‘situated’ cognitive science, that is, the kind of cognitive science that tries to take seriously the thought that human cognition is an achievement of creatures with a certain kind of body, which exist in relationships to their physical environment....
European Journal of Pharmacology
July 13, 2010
Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain.
Addiction Biology
July 2010
Francesco Angelucci, Valerio Ricci, Giovanni Martinotti et al.
The recreational drug 'ecstasy'[3,4-methylenedioxymethamphetamine (MDMA)] exerts a potent action on central serotonergic and dopaminergic neurons. These neurons utilize neurotrophins for their survival and function. In order to explore MDMA effects on neurotrophins, we measured by enzyme-linked immunosorbent assay the serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth...
Nature reviews. Neuroscience
July 2010
Katharina Henke
Prominent models of human long-term memory distinguish between memory systems on the basis of whether learning and retrieval occur consciously or unconsciously. Episodic memory formation requires the rapid encoding of associations between different aspects of an event which, according to these models, depends on the hippocampus and on consciousness. However, recent evidence indicates that the...
Journal of Pharmacology and Experimental Therapeutics
July 2010
Jennifer L. Stewart, Lance R Mcmahon
Marijuana-dependent individuals report using marijuana to alleviate withdrawal, suggesting that pharmacotherapy of marijuana withdrawal could promote abstinence. To identify potential pharmacotherapies for marijuana withdrawal, this study first characterized rimonabant-induced Delta(9)-tetrahydrocannabinol (Delta(9)-THC) withdrawal in rhesus monkeys by using drug discrimination and directly...
Journal of Northern Studies
July 1, 2010
Thomas A. DuBois
4 citations
Johan Turi’s Sámi deavsttat/Lappish Texts (1918–1919) is examined as a source of information regarding early twentieth-century Sami healing methods and hierarchies of medical resort. Turi’s account of traditional and personal healing experiences in the Čohkkeras/Jukkasjärvi district reflects complex processes of intercultural exchange and hybridization, in which Sami families availed themselves...
Biochemical Pharmacology
July 1, 2010
Hong-Wu Shen, Chao Wu, Xi-Ling Jiang et al.
40 citations
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural psychoactive indolealkylamine drug that has been used for recreational purpose. Our previous study revealed that polymorphic cytochrome P450 2D6 (CYP2D6) catalyzed 5-MeO-DMT O-demethylation to produce active metabolite bufotenine, while 5-MeO-DMT is mainly inactivated through deamination pathway mediated by monoamine oxidase (MAO). This...