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Mana December 1, 2013 Marcelo S. Mercante 30 citations
A ayahuasca é uma bebida psicoativa utilizada por diversos grupos indígenas por toda a Amazônia, assim como por xamãs mestiços (chamados "vegetalistas") e por religiões e grupos independentes no Brasil. Desde a década de 1990 esta bebida vem sendo empregada no tratamento da dependência. Existem atualmente alguns centros espalhados pela América do Sul que realizam este tipo de tratamento....
Behavioural Brain Research November 20, 2013 Martin A. Santini, D. Balu, M. Puhl et al.
Both the serotonin and glutamate systems have been implicated in the pathophysiology of schizophrenia, as well as in the mechanism of action of antipsychotic drugs. Psychedelic drugs act through the serotonin 2A receptor (5-HT2AR), and elicit a head-twitch response (HTR) in mice, which directly correlates to 5-HT2AR activation and is absent in 5-HT2AR knockout mice. The precise mechanism of...
European Journal of Pharmacology November 15, 2013 Aashish S Morani, Amy W M Ewald, Katherine M Prevatt-Smith et al.
κ Opioid receptor activation by traditional arylacetamide agonists and the novel neoclerodane diterpene κ opioid receptor agonist Salvinorin A (Sal A) results in attenuation of cocaine-seeking behavior in pre-clinical models of addiction. However, adverse effects such as sedation, depression and aversion limit their clinical utility. The Sal A analogue, 2-methoxy-methyl salvinorin B (MOM Sal B)...
British Journal of Pharmacology November 15, 2013 Ana Belén López-rodríguez, Alvaro Llorente‐berzal, Luis Miguel García‐segura et al. 50 citations
Background and Purpose Many young people consume ecstasy as a recreational drug and often in combination with cannabis. In this study, we aimed to mimic human consumption patterns and investigated, in male and female animals, the long‐term effects of Δ 9 ‐tetrahydrocannabinol ( THC ) and 3,4‐methylenedioxymethamphetamine ( MDMA ) on diverse neuroinflammation and neurotoxic markers. Experimental...
Frontiers in Psychology November 5, 2013 M. Jungert
From a philosophical point of view, the subject of Thomas Schramme's article seems to be well-known as he addresses one of the most prominent debates in both classical and contemporary philosophy: the mind-body problem. Of course, Schramme does not attempt to broadly cover this general issue. He rather focuses on the neglect of philosophical approaches within the context of the search for a...
PLoS One November 4, 2013 Alvaro Llorente‐berzal, Emma Puighermanal, Aurelijus Burokas et al. 43 citations
Ecstasy is a drug that is usually consumed by young people at the weekends and frequently, in combination with cannabis. In the present study we have investigated the long-term effects of administering increasing doses of delta-9-tetrahydrocannabinol [THC; 2.5, 5, 10 mg/kg; i.p.] from postnatal day (pnd) 28 to 45, alone and/or in conjunction with 3,4-methylenedioxymethamphetamine [MDMA; two...
Cognition November 2013 Bert Windey, Wim Gevers, Axel Cleeremans
Is visual awareness graded or binary? Experimental work has provided support for both possibilities, leading to two coexisting but contradictory theoretical accounts. Here we propose a promising candidate factor through which to integrate both accounts: the depth of stimulus processing required by the task. We compared color identification (a low-level task) with numerical judgements (a...
Nature Neuroscience November 2013 Zuzana Justinova, Paola Mascia, Hui-Qiu Wu et al.
In the reward circuitry of the brain, α-7-nicotinic acetylcholine receptors (α7nAChRs) modulate effects of Δ(9)-tetrahydrocannabinol (THC), marijuana's main psychoactive ingredient. Kynurenic acid (KYNA) is an endogenous negative allosteric modulator of α7nAChRs. Here we report that the kynurenine 3-monooxygenase (KMO) inhibitor Ro 61-8048 increases brain KYNA levels and attenuates...
The American Journal of Drug and Alcohol Abuse November 2013 Catherine Orr, Rowen Morioka, Brendan Behan et al.
Cannabis is the most commonly used illicit drug in adolescence. Heavy use is associated with deficits on a broad range of cognitive functions and heavy use during adolescence may impact development of gray and white matter. To examine differences in intrinsic brain activity and connectivity associated with cannabis dependence in adolescence using whole-brain voxelwise approaches. Adolescents...
Substance Abuse and Rehabilitation November 1, 2013 Jerry Meyer 93 citations
Ecstasy is a widely used recreational drug that usually consists primarily of 3,4-methylenedioxymethamphetamine (MDMA). Most ecstasy users consume other substances as well, which complicates the interpretation of research in this field. The positively rated effects of MDMA consumption include euphoria, arousal, enhanced mood, increased sociability, and heightened perceptions; some common...