Acta pharmacologica Sinica

ISSN 1745-7254

2 papers in the library · publishing 2017-2026

Papers

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The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit.

Acta pharmacologica Sinica May 19, 2026 Jun-Nan Xu, Jing-Ting Li, Ru-Xia Xu et al.

Diminished drive is one of the core symptoms of major depressive disorder (MDD) diagnosis, yet its underlying neural mechanisms remain elusive, primarily due to a lack of appropriate animal models. We developed a novel Multilevel Exploration Test (MET) apparatus to evaluate exploratory behavior, which is captured as a dynamic, stage-dependent process involving "search", "attend/investigate",...

DOI: 10.1038/s41401-026-01812-x Full text Anxiety Depression Ethology Motivation +1

Brain cannabinoid receptor 2: expression, function and modulation.

Acta pharmacologica Sinica March 2017 De-Jie Chen, Ming Gao, Fen-Fei Gao et al.

Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of molecules, some with psychoactive effects. At least 4% of the world's adult population uses cannabis annually, making it one of the most frequently used illicit drugs in the world. The psychoactive effects of cannabis are mediated primarily through cannabinoid receptor (CBR) subtypes. The prevailing...

DOI: 10.1038/aps.2016.149 Full text