Charles S. Peirce developed a process philosophy featuring a non-theistic agapistic evolution from nothingness. It is an Eastern inspired alternative to the Western mechanical ontology of classical science also inspired by the American transcendentalists. Advaitism and Buddhism are the two most important Eastern philosophical traditions that encompass scientific knowledge and the idea of...
Research has demonstrated the health benefits of a wide range of spiritual practices such as meditation and prayer, and similar nonspiritual practices like mindfulness. Shamanism is a spiritual practice that uses dream recall during ecstatic trances, and scientific research has shown health benefits of dream recall. Researchers have long realized the importance of intrapersonal communication...
The philosophy of Maurice Merleau-Ponty, a unique blend of existentialism and phenomenology, deserves to be better known in psychiatric-mental health nursing. This philosophy is particularly pertinent to the contemporary recovery movement that seeks to dispel the therapeutic nihilism regarding conditions such as schizophrenia, borderline personality, and substance use disorders. This paper...
Adult neurogenesis persists in the rodent dentate gyrus and is stimulated by chronic treatment with conventional antidepressants through BDNF/TrkB signaling. Ketamine in low doses produces both rapid and sustained antidepressant effects in patients. Previous studies have shed light on post-transcriptional synaptic NMDAR mediated mechanisms underlying the acute effect, but how ketamine acts at...
Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acute hallucinogen effects. HPPD was associated with a broader range of LSD (lysergic acid diethylamide)-like substances, cannabis, methylenedioxymethamphetamine (MDMA), psilocybin, mescaline, and psychostimulants. The recent emergence of novel...
Under the predictive coding framework, perceptual learning and inference are dependent on the interaction between top-down predictions and bottom-up sensory signals both between and within regions in a network. However, how such feedback and feedforward connections are modulated in the state induced by lysergic acid diethylamide (LSD) is poorly understood. In this study, an auditory oddball...
Scientific ReportsNovember 17, 2017Katja Weckmann, Michael J Deery, Julie A Howard et al.
Fewer than 50% of all patients with major depressive disorder (MDD) treated with currently available antidepressants (ADs) show full remission. Moreover, about one third of the patients suffering from MDD does not respond to conventional ADs and develop treatment-resistant depression (TRD). Ketamine, a non-competitive, voltage-dependent N-Methyl-D-aspartate receptor (NMDAR) antagonist, has been...
-methylcathinone) is a synthetic cathinone analog of the recreational drug ecstasy. Although it is marketed to recreational users as relatively safe, fatalities due to hyperthermia, serotonin syndrome, and multi-organ system failure have been reported. Since psychopharmacological data remain scarce, we have focused our research on pharmacokinetics, and on a detailed evaluation of temporal...
IntroductionPeganum harmala (Zygophyllaceae) is an herb native to the dry area of the Mediterranean east to northern India.The plant originated in Central Asia, but now grows wild in Africa, Middle East, India, South America, Mexico, and Southern USA [1].Seeds of Peganum harmala are growing widespread in Egypt.They are used as an anti-hemorrhoid and central nervous system (CNS) stimulating...
The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working...