Zenodo (CERN European Organization for Nuclear Research)
October 13, 2026
Adam Cupell
preprint
Abstract Debate about artificial intelligence and consciousness has centered on one question: is AI conscious? At The Science of Consciousness conference (TSC 2026, San Diego), the prevailing answer was no, supported by substantial argument and data. This paper proposes that the question, however well answered, is not the most productive one. It offers a reframe first posed by the author at TSC...
October 13, 2026
Nunzia La Maida, Lourdes Poyatos, Annagiulia Di Trana et al.
Background and Purpose: Clophedrone (3-chloromethcathinone, 3-CMC) belongs to the methcathinone subclass of ring-substituted cathinones, a prominent group of new psychoactive substances (NPS) present in the illicit drug market. To date no studies have assessed concentrations and acute effects of 3-CMC in humans after self-administration. Experimental Approach: A total of 16 psychostimulant...
Journal of Latin American Cultural Studies
October 13, 2026
Francisco Quinteiro Pires
By drawing on shamanic dreaming, this article approaches the conceptualisations of Indigenous thinkers, such as Davi Kopenawa Yanomami and Ailton Krenak, who envision a future of interdependence and care between human beings and all matter on Earth, increasingly harmed by predatory capitalism. It specifically explores the visuality of the Yanomami cosmology and Ailton Krenak’s concept of...
Zenodo (CERN European Organization for Nuclear Research)
October 12, 2026
George Wanjau
preprint
Abstract In depersonalization and derealization (DPDR), patients report that the self and the surrounding world feel unreal, remote, or dreamlike, while memory, reasoning, and perception remain intact on objective testing. This presents a paradox: the components of self-experience appear individually preserved, yet the experience as a whole loses its felt reality. Prevailing accounts localize...
Scientific Reports
October 12, 2026
Zhenjiang Liao, Qiuping Huang, Xinxin Chen et al.
Etomidate, a short-acting GABA_A receptor modulator and emerging novel psychoactive substance, is increasingly abused non-medically. Despite rising clinical concern, the neuropsychological profiles of etomidate use disorder (EUD) remain poorly characterized, prompting this systematic investigation of its clinical and neurophysiological features. 152 individuals with EUD and 67 age-matched...
Asian Journal of Psychiatry
October 12, 2026
Gia Han Le, Sabrina Wong, Simryn Selby et al.
Ketamine is a rapid-acting antidepressant with demonstrated efficacy in major depressive disorder and treatment-resistant depression, yet the mechanisms by which its molecular actions translate into sustained clinical improvement remain incompletely understood. Prevailing models have emphasized N-methyl-D-aspartate receptor antagonism and downstream glutamatergic signaling; however, convergent...
Lviv University Herald Series Psychological sciences
October 12, 2026
Ruslan Hanushchak, Игорь Прись
У статті здійснено ретроспективний огляд розвитку психоделічної терапії та проаналізовано сучасний стан досліджень її ефективності у лікуванні психічних розладів. Простежено еволюцію використання психоделічних речовин – від традиційних духовних і лікувальних практик корінних народів через ранні клінічні дослідження середини ХХ століття до сучасного етапу, так званого «психоделічного ренесансу»....
Molecular Neurobiology
October 12, 2026
Daiane Momo Daneluz, Alana Sueli Dos Santos, Silvana Regina De Melo et al.
Psychedelic drugs promote rapid neuroplasticity in brain regions affected by trauma exposure, such as the prelimbic (PL) cortex and the dorsal hippocampus (DH), being investigated as potential treatments for posttraumatic stress disorder. Ayahuasca (Aya) contains N,N-dimethyltryptamine, a classic psychedelic. Our previous work showed that Aya reduces fear expression by impairing fear memory...
Zenodo (CERN European Organization for Nuclear Research)
October 11, 2026
Rajveer Solanki
preprint
This paper introduces the Mechanism of Vector Replication, an original framework in the philosophy of mind and cognitive science that addresses how human communication succeeds despite isolated, subjective internal experiences (qualia). Modeling the biological brain as an independent "rendering engine," the framework breaks down perception into a five-step processing sequence: external...
bioRxiv (Cold Spring Harbor Laboratory)
October 11, 2026
Ratna Mahathi Vuruputuri, Vaishnavi Reghunath, Shreyasi Mukherjee et al.
preprint
Abstract Background The head-twitch response (HTR) is a serotonin 2A receptor (5-HT 2A R) dependent behavioral correlate of serotonergic psychedelic action in rodent models. Although cortical 5-HT 2A Rs have been implicated in HTRs, the contribution of specific cortical circuits to this behavior remains poorly defined, with a few reports implicating the medial prefrontal cortex (mPFC) in the...