Ayahuasca is a psychoactive beverage prepared traditionally from a mixture of the leaves and stems of Psychotria viridis and Banisteriopsis caapi, respectively, being originally consumed by indigenous Amazonian tribes for ritual and medicinal purposes. Over the years, its use has spread to other populations as a means to personal growth and spiritual connection. Also, the recreational use of...
Objective. This article aims to offer a vision of the centers at a global level that use derivatives of plants or animals for the treatment of substance use disorders, and to offer a reflection on the concept of drugs as medicinal or toxicant agents depending on the context of use, culture and policy. Methodology. Some practices coming from Africa, Asia, Europe and the Americas were considered,...
Objective: Ayahuasca tea contains N, N-dimethyltryptamine (DMT) found in the leaves of the Psychotria viridis vine and -carbolines found in Banisteriopsis caapi.Case Report: A 59-year-old man was brought to the emergency department due to hallucinations, agitated behavior, aggression , nausea and vomiting developing 1.5 h after drinking approximately one tea glassful of Ayahuasca tea....
Ayahuasca is a brew prepared from the water decoction of two Amazonian plants, which is legally used for religious, cultural or therapeutic activities. The potential use of ayahuasca as a natural or phytotherapeutic drug is directly linked to the action of its active compounds and their connection with the therapeutic efficacy of the beverage. In this context, the aim of the present study was...
INTRODUCTION: The pineal gland is a photo-neuro-endocrine organ situated inside the brain, that secretes serotonin, melatonin and N,N-dymethyltriptamine. This narrative review will address the latest information gathered on this function of the gland as well as the unknown roles it may have. The different histological and pathological findings of the pineal gland have demonstrated a role in...
Introduction PCP was synthesized in 1956 by Maddox and was established as a potent general anaesthetic, but it was early discontinued due to more frequent adverse drug reactions than expected. Later, PCP became a popular street drug. We report 3 cases of people who consumed PCP: 1 typical clinical case and also 2 others cases with PCP on drug urine testing. Case reports Case 1: a 36-year-old...
N, N-dimethyltryptamine (DMT) is an indole alkaloid produced by a number of plants and animals, including humans. Its psychoactive effects were first described in 1956 by Stephen Szára, but have been exploited for centuries by South American indigenous populations in the form of ayahuasca. In the present review, we assess the state of the art regarding a putative role for endogenous DMT and...
Naturally occurring and psychedelic drug-occasioned experiences interpreted as personal encounters with God are well described but have not been systematically compared. In this study, five groups of individuals participated in an online survey with detailed questions characterizing the subjective phenomena, interpretation, and persisting changes attributed to their single most memorable God...
RationaleDepressive syndrome or depression is a debilitating brain disorder affecting numerous people worldwide. Although readily available, current antidepressants have low remission rates and late onset times. Recently, N-methyl-D-aspartate (NMDA) receptor antagonists, like ketamine and methoxetamine (MXE), were found to elicit rapid antidepressant effects. As the search for...