SAGE Open Medicine
2013
Eduardo E Schenberg
28 citations
Objectives: Comprehensively review the evidence regarding the use of ayahuasca, an Amerindian medicine traditionally used to treat many different illnesses and diseases, to treat some types of cancer. Methods: An in-depth review of the literature was conducted using PubMed, books, institutional magazines, conferences and online texts in nonprofessional sources regarding the biomedical knowledge...
December 1, 2012
D. Compton, Melissa C. Selinger, E. Westman et al.
Fo xy or Methoxy Fo xy (5-MeO-DIPT) is one of a series of new "club drugs" that within the past decade has gained in popularity among recreational users as an alternative to MDMA (Ecstasy). Unlike M DMA, not much is known about the neurobiological consequences of 5-MeO-DIPT use. Little is known about the effects of either co mpound on learning in a nonspatial appetitive task. In the present...
Journal of agricultural and food chemistry
September 19, 2012
Luigi Servillo, Alfonso Giovane, Maria Luisa Balestrieri et al.
The occurrence of N-methylated tryptamine derivatives in bergamot plant (Citrus bergamia Risso et Poit) is reported for the first time. Interestingly, the most abundant of these substances is N,N,N-trimethyltryptamine, which has not been previously identified in any citrus plant. The N-methylated tryptamine derivatives were identified and quantitated in leaves, peel, juice, and seeds by...
PLoS One
August 8, 2012
José Carlos Bouso, Débora González, Sabela Fondevila et al.
313 citations
Ayahuasca is an Amazonian psychoactive plant beverage containing the serotonergic 5-HT(2A) agonist N,N-dimethyltryptamine (DMT) and monoamine oxidase-inhibiting alkaloids (harmine, harmaline and tetrahydroharmine) that render it orally active. Ayahuasca ingestion is a central feature in several Brazilian syncretic churches that have expanded their activities to urban Brazil, Europe and North...
Drug and Alcohol Dependence
July 1, 2012
Raimondo Bruno, Allison J Matthews, Matthew Dunn et al.
58 citations
The past decade has seen the development of an array of emerging psychoactive substances (EPS), however, there is minimal information on the extent of their use outside Europe. This study aimed to determine the extent of use of EPS from stimulant (such as mephedrone) and psychedelic classes (such as 5-methoxy-dimethyltryptamine [5-MeO-DMT]) among an Australian sample of regular ecstasy users...
Journal of Psychoactive Drugs
July 1, 2012
Mitchell B. Liester, James I. Prickett
78 citations
Ayahuasca is a medicinal plant mixture utilized by indigenous peoples throughout the Amazon River basin for healing purposes. The "vine of the soul" or "vine of death," as it is known in South America, contains a combination of monoamine oxidase inhibitors and N,N-dimethyltryptamine (DMT). When ingested together, these medicines produce profound alterations in consciousness. Increasingly,...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
June 10, 2012
Daniel I. Brierley, Colin Davidson
133 citations
Ayahuasca is a hallucinogenic botanical mixture originating in the Amazon area where it is used ritually, but is now being taken globally. The 2 main constituents of ayahuasca are N,N-dimethyltryptamine (DMT), a hallucinogen, and harmine, a monoamine oxidase inhibitor (MAOI) which attenuates the breakdown of DMT, which would otherwise be broken down very quickly after oral consumption. Recent...
The FASEB Journal
April 1, 2012
Ai-Ming Yu
Indolealkylamine (IAA) drugs are a major class of serotonin analogs that have high impact as substances of abuse. Among them, 5‐methoxy‐ N,N ‐dimethyltryptamine (5‐MeO‐DMT) was placed into Schedule I controlled substance status in the United States as of January 19, 2011, which is often co‐abused with harmaline. IAA drugs acts mainly on the serotonin neurotransmission system. Overdose of one...
The open neuropsychopharmacology journal
2012
Devon L Graham, Nicole R Herring, Tori L. Schaefer et al.
4 citations
The abuse of drugs such as methamphetamine (MA), 3,4-methylenedioxymethamphetamine (Ecstasy, MDMA), and 5-methoxydiisopropyltryptamine (5-MeO-DIPT; Foxy) is global. Symptoms from taking these drugs include tachycardia, agitation, hyperpyrexia, and sometimes seizures. We compared the EEG effects of these drugs in male Sprague-Dawley rats (~300 g) implanted with cortical electroencephalographic...
Drug Testing and Analysis
2012
Paulo César Ribeiro Barbosa, Suely Mizumoto, Michael P. Bogenschutz et al.
112 citations
Ayahuasca is a psychedelic brew originally used for magico-religious purposes by Amerindian populations of the western Amazon Basin. Throughout the last four decades, the use of ayahuasca spread towards major cities in all regions of Brazil and abroad. This trend has raised concerns that regular use of this N,N-dimethyltryptamine- and harmala-alkaloid-containing tea may lead to mental and...