The Natural Products JournalAugust 12, 2026Weslany Souza Rocha, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior et al.
Introduction: Mimosa tenuiflora (Willd.) Poir., widely known as Jurema preta in Brazil and tepezcohuite in Mexico, is a perennial shrub or tree traditionally used in folk medicine across the Caatinga biome of northeastern Brazil and other regions of Central and South America. Tryptamine is an indole alkaloid naturally found in several species, with M. tenuiflora representing an important...
Alternative healthcare practices using psychedelic “plant medicines,” such as ayahuasca, challenge current prohibition and mainstream healthcare frameworks. Despite the criminalization of ayahuasca's active component, N,N-dimethyltryptamine (DMT), Australian ayahuasca dietero networks have developed sophisticated healthcare systems with systematic assessment processes, safety mechanisms, and...
BACKGROUND AND AIMS: This study qualitatively explored psychological change processes as described by participants and therapists within a phase 2a clinical trial evaluating the safety, tolerability, and preliminary efficacy of a single dose of intranasal 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; BPL-003) administered alongside psychological support and manualised cognitive behavioural...
Zusammenfassung Klassische Halluzinogene („Psychedelika“) wie Lysergsäurediethylamid (LSD), Psilocybin, N,N-Dimethyltryptamin (DMT) und 5-Methoxydimethyltryptamin (5-MeO-DMT) werden zurzeit wieder als potenzielle Behandlungsoptionen bei Substanzgebrauchsstörungen untersucht. Psychedelika entfalten ihre Wirkung über eine Aktivierung von serotonergen 5HT-2a Rezeptoren im zentralen Nervensystem,...
Set, setting, preparation, and integration are widely recognized as important dimensions of psychedelic experiences. However, these concepts often remain too general to specify how preparation, containment, and aftercare should differ across substances, routes of administration, acute duration, residual effects, bodily condition, and interaction exposure. This article proposes the...
Visionary art, inspired by the shift in perspective towards a (hyper)spatial horizon, represents a departure from the postmodern ethos. Rather than simply remixing established cultural signifiers, these images function as portals to divergent ontological realms and non-human visual paradigms. Focusing on the agency of non-human entities and dimensions, this paper proposes a new methodology for...
Classic psychedelics, including psilocybin, LSD, DMT, 5-MeO-DMT, mescaline, and phenethylamines such as DOI, exert their core effects through 5-HT2A receptor agonism, inducing widespread neurobiological and behavioral changes relevant to psychiatric research. Emerging evidence suggests that these effects are modulated by sex, yet this dimension remains underrepresented in studies. This review...
Negative self-referential emotions such as embarrassment and shame play a key role in the psychopathology of psychiatric disorders but are often insufficiently addressed by standard treatments. Psychedelics such as ayahuasca - an Amazonian plant decoction containing the psychedelic N,N-dimethyltryptamine (DMT) and harmala alkaloids, have been proposed to positively modulate self-referential...
A resurgent therapeutic frontier, the contemporary renaissance in psychedelic science has accelerated investigation of classic serotonergic psychedelics (psilocybin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), mescaline), empathogenic entactogenic agents (3,4-methylenedioxymethamphetamine (MDMA)), and glutamatergic dissociatives (ketamine) as adjuncts to psychotherapy. While...
Classic psychedelics such as lysergic acid diethylamide (LSD), psilocybin, N,N-dimethyltryptamine (DMT), and mescaline induce lasting changes in neuroplasticity and behavior that extend far beyond their acute pharmacological effects. Emerging evidence highlights that these enduring therapeutic benefits in neuropsychiatric conditions may be significantly mediated through complex epigenetic...