Analogues of 4-phosphoryloxy-N,N-dimethyltryptamine (psilocybin) are being sold on recreational drug markets and developed as potential medications for psychedelic-assisted therapies. Many of these tryptamine-based psilocybin analogues produce psychedelic-like effects in rodents and humans primarily by agonist activity at serotonin 2A receptors (5-HT2A). However, the comprehensive...
There is growing interest in the therapeutic potential of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) for psychiatric disorders. Although 5-MeO-DMT can be chemically synthesized, the parotoid gland secretions of Incilius alvarius (also known as the Colorado River or Sonoran Desert toad) contain 5-MeO-DMT and other molecules including bufotenine, bufagenins, bufotoxins, and indole alkylamines...
AbstractAimThis study examines narratives describing complex psychedelic experiences after smoking N,N-dimethyltryptamine.MethodsThe narrative accounts examined here were gathered from a variety of online sites and analyzed in order to discover themes, categories and patterns in the phenomenon of the resulting psychedelic experiences.ResultsSubjects reported seeing complex and unusual visual...
N,N-dimethyltryptamine (DMT) belongs to a class of drugs known as serotonergic psychedelics, which produce profound shifts in consciousness by dramatically altering perception and causing hallucinatory phenomena. In humans, DMT has a rapid onset and the effects, which include feelings of dissociation from external reality, entering into an ‘otherworldly dimension’, and intense internal visual...
AMA Schimmelpfennig J, Jankowiak-Siuda K. Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders. Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii. 2023;39(2):115-130. doi:10.5114/fpn.2023.131979. APA Schimmelpfennig, J., & Jankowiak-Siuda, K. (2023). Therapeutic potential of N,N-dimethyltryptamine in...
AMA Schimmelpfennig J, Jankowiak-Siuda K. Unique biological and physiological properties of endogenous N, N-dimethyltryptamine from the perspective of functioning of the nervous system. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology. 2023;18(1):1-10. doi:10.5114/nan.2023.129068. APA Schimmelpfennig, J., & Jankowiak-Siuda, K. (2023). Unique biological and physiological...
Abstract Consumption of the psychedelic brew ayahuasca is a central ritualistic aspect of the Santo Daime religion. The current observational, baseline controlled study was designed to assess whether members (n = 24) of the Santo Daime church would show enhanced capacity for mental imagery during an ayahuasca experience. In addition, this study assessed whether the effects of ayahuasca on...
Recently, the Amazonian plant medicine "ayahuasca"-containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine-has been suggested to exhibit beneficial effects in patients with affective and other mental health disorders. Although ayahuasca ingestion is considered safe, its pharmacokinetics/pharmacodynamics and tolerability profile pose...
Abstract Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of arousal. Here, we performed chronic electrophysiological recordings from the cortex concomitant with pupillometry in freely moving adult male mice following an injection of a...
Background The psychedelic 5-MeO-DMT has shown clinical potential due to its short duration and ability to induce mystical experiences. However, a phenomenon known as “reactivations” (similar to “flashbacks”) is a poorly understood and frequently reported phenomenon which appears associated with 5-MeO-DMT use and warranted further investigation. Aims This study examined whether differences in...