Psychopharmacology
July 14, 2026
Helena Aicher, Joëlle Dornbierer, Luzia Caflisch et al.
Negative self-referential emotions such as embarrassment and shame play a key role in the psychopathology of psychiatric disorders but are often insufficiently addressed by standard treatments. Psychedelics such as ayahuasca - an Amazonian plant decoction containing the psychedelic N,N-dimethyltryptamine (DMT) and harmala alkaloids, have been proposed to positively modulate self-referential...
ACS Medicinal Chemistry Letters
July 10, 2026
Anna C. Renner, Robert B. Kargbo
High Resolution Image Download MS PowerPoint Slide The psychedelic therapeutics field continues to evolve beyond classical hallucinogens toward integrated treatment platforms that combine optimized pharmacology, drug delivery, and clinical implementation. Recent patent applications disclose selective 5-HT2A receptor activators, precision aerosol delivery technologies for psychedelic compounds,...
ACS Chemical Neuroscience
July 9, 2026
José Alexandre Salerno, Elizabeth R. Dominguez, Karina Karmirian et al.
The serotonergic psychedelic N,N-dimethyltryptamine (DMT) produces rapid antidepressant effects in preclinical and early clinical studies. Therapeutic benefits have been linked to sustained neural plasticity, including adult neurogenesis in rodents. Whether brief DMT exposure engages proliferative responses in human neural stem cells (NSCs) remains unresolved. Using human iPSC-derived NSCs, we...
Journal of Psychopharmacology
July 8, 2026
Raynara Bolcont, Fernanda Palhano-Fontes, Handersson Barros et al.
BACKGROUND: -dimethyltryptamine (DMT); however, long-term effects, including broader well-being dimensions, are sparsely explored across populations. AIMS: Investigating whether DMT produces sustained improvements in anxiety, life satisfaction, and quality of life, in both healthy individuals and patients with treatment-resistant depression (TRD). METHODS: In 2 open-label clinical trials, 27...
Zenodo (CERN European Organization for Nuclear Research)
July 2, 2026
Eugene Catrambone
This paper develops a unified framework linking psychedelic neuropharmacology, microtubule biophysics, and spacetime information theory. Building on prior work (Consciousness and the Scalar Clock, Consciousness as Recursive Spacetime Projection, and Consciousness, Information, and Null Constraints), it proposes that N,N-dimethyltryptamine (DMT) alters subjective time by modulating microtubule...
Metabolic Engineering Communications
July 1, 2026
Lucas Henrique Junges, Flávia Lada Degaut Pontes, Francisco J. Teles Mota et al.
N,N-dimethyltryptamine (DMT) is a bioactive indole alkaloid that could greatly benefit from scalable, fermentation-based production for research and pharmaceutical applications. In this study, we reconstructed a two-step bacterial pathway converting L-tryptophan to DMT via tryptamine. This involved combining a pyridoxal 5'-phosphate (PLP)-dependent tryptophan decarboxylase from the bacterium...
Neuropharmacology
July 1, 2026
Anne Nathalia De Sousa-Silva, Clarissa de Almeida Moura, Carina Ioná De Oliveira Torres et al.
1 citation
N,N-dimethyltryptamine (DMT) is an naturally occurring indoleamine with hallucinogenic and antidepressant effects in humans. Here, we compared the effects of DMT and S-ketamine, a fast-acting antidepressant, in helpless mice. To induce helplessness, male single and group-housed mice were exposed to inescapable footshock stress; only helpless animals were subsequently treated with S-ketamine 10...
Clinical pharmacology and therapeutics
July 1, 2026
Tijana Stojanovic, Kent W Nilsson, Robert Fredriksson et al.
Interest in ayahuasca and its main component, N,N-Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited. We therefore systematically examined registered interventional trials of DMT, ayahuasca, and DMT combined with...
Zenodo (CERN European Organization for Nuclear Research)
July 1, 2026
Schüller Thomas
DMT und Ayahuasca / DMT and Ayahuasca Eigenständiges bilinguales Vollwerk (DE+EN). Transdisziplinäre wissenschaftliche Übersicht zu DMT und Ayahuasca entlang acht Disziplinen, mit expliziter Geltungsstufen-Kennzeichnung (gesichert / wahrscheinlich / offen). **Schwesterwerke (gleiche Struktur):** FORSCH-0291 (LSD) · FORSCH-0350 (Psilocybin) · FORSCH-0351 (Meskalin) **Theorieanker:** FORSCH-0083...