DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines.
Richard A Glennon, R Young, John M. Jacyno, M Slusher, John A. Rosecrans
European Journal of Pharmacology January 21, 1983 DOI: 10.1016/0014-2999(83)90196-6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal behavioral pharmacology study (drug discrimination) Peer reviewed |
|---|---|
| Population | Rats trained in a two-lever operant drug discrimination procedure |
| Interventions | LSD N beta-carboline derivatives |
| Dose | 1.0 mg/kg DOM (training dose) |
| Measures | ED50 values from drug discrimination, human hallucinogenic potency |
| Topics | LSD |
| Key points | Suggests that LSD and several alpha-methyltryptamine, N,N-dialkyltryptamine, and beta-carboline derivatives produce stimulus effects similar to those of DOM in rats. For twelve agents with human data, a significant correlation is reported between discrimination-derived ED50 values and hallucinogenic potency. |
Abstract
Stimulus generalization studies were conducted using rats trained to discriminate 1.0 mg/kg of the phenalkylamine hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a two-lever operant procedure. The results suggest that certain indolealkylamine hallucinogens, including LSD and several alpha-methyltryptamine, N,N-dialkyltryptamine and beta-carboline derivatives, are capable of producing stimulus effects similar to those produced by DOM. Furthermore, for twelve agents where human data are available, a significant correlation exists between discrimination-derived ED50 values and hallucinogenic potency.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
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- Neuropharmacology of N,N-dimethyltryptamine Brain Research Bulletin April 30, 2016
- Psychedelic-inspired drug discovery using an engineered biosensor. Cell April 28, 2021
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Cites 7
- The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine American Journal of Psychiatry February 1, 1976
- Steric and Electronic Relationships among Some Hallucinogenic Compounds Proceedings of the National Academy of Sciences September 1, 1970
- COMPARISON OF THREE PSYCHOTROPIC DRUGS (PSILOCYBIN, JB-329, AND IT-290) IN VOLUNTEER SUBJECTS The Journal of Nervous and Mental Disease November 1, 1960
- Dimethyltryptamine Experiments with Psychotics Journal of Mental Science April 1, 1958
- Psychological Effects and Metabolism of N,N-diethyltryptamine in Man Archives of General Psychiatry September 1, 1966
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