A comparison of the behavioral effects of DOM homologs.
Richard A Glennon, R Young, John A. Rosecrans
Pharmacology, Biochemistry, and Behavior April 1982 DOI: 10.1016/0091-3057(82)90414-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal drug discrimination study Peer reviewed |
|---|---|
| Sample size | 24 |
| Population | Rats trained to discriminate (+/-)-DOM from saline |
| Interventions | (+/-)-DOM DOET DOPR DOBU DOTB DOAM |
| Dose | 1.0 mg/kg (+/-)-DOM |
| Key points | The (+/-)-DOM discriminative stimulus generalized to DOET, DOPR, DOBU, and the DOET isomers, but only partially to DOTB and DOAM, suggesting the latter two compounds produce different stimulus properties. ED50 values for compounds showing full generalization correlated strongly (r2 = 0.94) with their human hallucinogenic potencies. |
Abstract
Twenty-four rats, trained to discriminate 1.0 mg/kg of (+/-)-DOM, i.e. (+/-)-2,5-dimethoxy-4-methylphenylisopropylamine, from saline under a VI-15 schedule of reinforcement, were challenged with a series of DOM homologs. The agents examined included the 4-ethyl (DOET), -propyl (DOPR), -butyl (DOBU), -tertiary butyl (DOTB) and -amyl (DOAM) derivatives as well as the R(-)- and S(+)-isomers of DOET. The (+/-)-DOM stimulus was found to generalize to all of the agents, except DOTB and DOAM, where only partial generalization occurred. The results suggest that the stimulus properties produced by the latter two compounds may differ from those of the remainder of the series. Furthermore, the ED50 values obtained, for those compounds to which the DOM-stimulus generalized, correlated significantly (r2 = 0.94) with the human hallucinogenic potencies of these agents.
Citations in the library
Cited by 8
- Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. Neuropharmacology May 1, 2020
- Effect of Hallucinogens on Unconditioned Behavior Current Topics in Behavioral Neurosciences 2016
- Structure–activity relationships of serotonin 5‐HT2Aagonists Wiley Interdisciplinary Reviews Membrane Transport and Signalling February 28, 2012
- Effect of a Chiral 4-Alkyl Substituent in Hallucinogenic Amphetamines Journal of Medicinal Chemistry September 1, 1995
- Use of the head-twitch response to investigate the structure–activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines Psychopharmacology December 7, 2022
and 3 more in the library
Cites 6
- The effects of lysergic acid diethylamide and mescaline-derived hallucinogens on sensory-integrative function: tactile startle. Journal of Pharmacology and Experimental Therapeutics December 1, 1978
- Psychotomimetic phenylisopropylamines. 5. 4-Alkyl-2,5-dimethoxyphenylisopropylamines Journal of Medicinal Chemistry December 1, 1975
- The effects of 2,5-dimethoxy-4-methylamphetamine (DOM), 2,5-dimethoxy-4-ethylamphetamine (DOET), d-amphetamine, and cocaine in rats trained with mescaline as a discriminative stimulus Psychopharmacology 1975
- Behavioral properties of psychoactive phenylisopropylamines in rats. European Journal of Pharmacology December 17, 1981
- DOM and related 2,5-dimethoxy-4-alkylphenylisopropylamines: behavioral and serotonin receptor properties. Pharmacology, Biochemistry, and Behavior March 1981
and 1 more in the library