Psychological Effects and Metabolism of N,N-diethyltryptamine in Man
Archives of General Psychiatry September 1, 1966 DOI: 10.1001/archpsyc.1966.01730150096014 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled trial Peer reviewed |
|---|---|
| Sample size | 20 |
| Population | Chronic schizophrenic patients and normal volunteers |
| Intervention | DET |
| Dose | 1 mg/kg |
| Topics | Mescaline |
| Keywords | Tryptamines Lysergic acid Metabolism Skatole Indole test Hydroxylation Stereochemistry Pharmacology Biochemistry Enzyme |
| Citations | 33 |
| Key findings | The study compared DET metabolism in chronic schizophrenic patients and normal volunteers to correlate the rate of DET metabolism with psychological effects. |
Abstract
SIMPLE INDOLE derivatives like the alkylated tryptamines, N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET), produce psychotogenic-like symptoms similar to lysergic acid diethyemide (LSD) and mescaline.1-4 One of the important metabolic pathways of DET has been shown to be by 6-hydroxylation.5The known metabolic pathways of DET are summarized in Fig 1. Other investigators have reported that naturally occurring indole derivatives, ie, tryptamine itself, skatole, melatonin, can also be hydroxylated in the six position.6-8This suggests the possibility that this enzyme system might be involved in spontaneously occurring psychoses. The present study was undertaken to compare the metabolism of DET in a group of chronic schizophrenic patients and in a group of normal volunteers and to correlate the individual rate of DET metabolism with the psychological effects in man. Methods Experimental Procedure.—A 1 mg/kg dose of DET was administered intramuscularly to ten normal
Comparable studies
Other non-randomized and open-label trials on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The paradoxical psychological effects of lysergic acid diethylamide (LSD) Healthy volunteers | 2016 | Within-subjects controlled trial | n = 20 |
| DOET(2,5-Dimethoxy-4-Ethylamphetamine), a New Psychotropic Drug Normal male subjects | 1971 | Controlled trial | |
| Pharmacokinetics, Pharmacodynamics, and Urinary Recovery of Oral Mescaline Hydrochloride in Healthy Participants. Healthy human participants | 2025 | Clinical trial (phase I) | n = 49 |
Citations in the library
Cited by 10
- Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. Neuropharmacology May 1, 2020
- Recreational Use, Analysis and Toxicity of Tryptamines Current Neuropharmacology December 10, 2014
- Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants. Translational Psychiatry May 23, 2023
- Toxicology and Analysis of Psychoactive Tryptamines International Journal of Molecular Sciences December 4, 2020
- DPT as an Adjunct in Brief Psychotherapy with Cancer Patients OMEGA - Journal of Death and Dying February 1, 1980
and 5 more in the library