Discriminative stimulus properties of phenylisopropylamine derivatives.
Drug and Alcohol Dependence June 1986 DOI: 10.1016/0376-8716(86)90003-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal drug-discrimination study Peer reviewed |
|---|---|
| Population | Animals trained to discriminate (+)-amphetamine or (+/-)-DOM from saline |
| Interventions | (+)-Amphetamine (+/-)-DOM |
| Key points | The text reports that methoxy-substituted and related phenylisopropylamines were classified by stimulus generalization in animals trained to discriminate amphetamine or DOM from saline, separating compounds with amphetamine-like effects from those with DOM-like effects. Specific results and compound classifications are not given in the abstract. |
Abstract
The phenylisopropylamine unit is a common structural fragment amongst many centrally-acting agents. However, these agents do not necessarily produce similar behavioral effects in test subjects. For example, the phenylisopropylamine derivative amphetamine is a central nervous system (CNS) stimulant whereas its 2,5-dimethoxy-4-methyl analog, i.e. DOM, is considered to be a hallucinogen. Employing animals trained to discriminate either (+)-amphetamine or (+/-)-DOM from saline in a two-lever operant procedure, stimulus generalization studies were conducted to evaluate members of a series of methoxy-substituted, and related, phenylisopropylamines. In this manner, it was possible to classify these agents as to which produced amphetamine-like effects, and which produced DOM-like effects.
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- The role of 5-HT2A, 5-HT2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice Psychopharmacology July 2, 2014
- Novel Psychoactive Substances—Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs Frontiers in Psychiatry August 18, 2017
- Impure but not inactive: Behavioral pharmacology of dibenzylpiperazine, a common by-product of benzylpiperazine synthesis Journal of Psychopharmacology June 18, 2018
- The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse. Journal of Medicinal Chemistry March 15, 2017
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Cites 7
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- MDA: a psychoactive agent with dual stimulus effects. Life Sciences January 23, 1984
- 1-(2,3-Methylenedioxyphenyl)-2-aminopropane (2,3-MDA): a preliminary investigation. General pharmacology 1984
- Indolealkylamine and phenalkylamine hallucinogens. Effect of alpha-methyl and N-methyl substituents on behavioral activity. Biochemical Pharmacology April 1, 1983
- Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane. Journal of Medicinal Chemistry October 1982
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