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1-(2,3-Methylenedioxyphenyl)-2-aminopropane (2,3-MDA): a preliminary investigation.

Richard A Glennon, R Young, W Soine

General pharmacology 1984 DOI: 10.1016/0306-3623(84)90016-8 (opens in new tab)

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AI-extracted from the abstract
Characteristics Drug discrimination study Peer reviewed
Population Rats
Interventions 2 3-MDA (+)-amphetamine (+/-)-DOM (+/-)-3 4-MDA
Key points 2,3-MDA, a positional isomer of 3,4-MDA, did not produce amphetamine- or DOM-appropriate responding in drug-discrimination tests, but the 3,4-MDA stimulus generalized to 2,3-MDA, indicating shared discriminative stimulus effects between the two isomers.

Abstract

Rats trained to discriminate saline from either (+)-amphetamine, (+/-)-DOM, or (+/-)-3,4-MDA in a two-lever drug discrimination paradigm were administered doses of a novel positional isomer of 3,4-MDA, i.e. 2,3-MDA. The novel isomer produced neither amphetamine-appropriate nor DOM-appropriate responding: the 3,4-MDA stimulus did, however, generalize to 2,3-MDA.

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