2,3-MDA, a positional isomer of 3,4-MDA, did not produce amphetamine- or DOM-appropriate responding in drug-discrimination tests, but the 3,4-MDA stimulus generalized to 2,3-MDA, indicating shared discriminative stimulus effects between the two isomers.
Abstract
Rats trained to discriminate saline from either (+)-amphetamine, (+/-)-DOM, or (+/-)-3,4-MDA in a two-lever drug discrimination paradigm were administered doses of a novel positional isomer of 3,4-MDA, i.e. 2,3-MDA. The novel isomer produced neither amphetamine-appropriate nor DOM-appropriate responding: the 3,4-MDA stimulus did, however, generalize to 2,3-MDA.