Discriminative stimulus properties of DOM and several molecular modifications.
Richard A Glennon, R Young, John A. Rosecrans
Pharmacology, biochemistry, and behavior April 1982 DOI: 10.1016/0091-3057(82)90413-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats trained to discriminate racemic DOM from saline |
| Interventions | racemic 2 R(-)-DOM S(+)-DOM (+/-)-2 5-dimethoxyphenylisopropylamine (2 5-DMA) R(-)-2 5-DMA 2-demethyl derivative of (+/-)-DOM 3-methyl positional isomer of (+/-)-DOM S(+)-2 5-demethyl derivative of (+/-)-DOM |
| Dose | 1.0 mg/kg for (+/-)-DOM training dose; other doses not specified |
| Key findings | The discriminative stimulus effects of racemic DOM generalized to its R(-) and S(+) isomers, to 2,5-DMA and R(-)-2,5-DMA, and to the 2-demethyl derivative of DOM. The 3-methyl isomer produced only 34% DOM-appropriate responding at the highest dose tested, and S(+)-2,5-DMA and the 5-demethyl derivative disrupted behavior. |
Abstract
Rats trained to discriminate racemic 2,5-dimethoxy-4-methylphenylisopropylamine, (+/-)-DOM (1.0 mg/kg), from saline in a two-lever drug discrimination task were challenged with the optimal isomers of DOM as well as with several related agents which represent minor molecular modifications of the DOM structure. Generalization of the (+/-)-DOM stimulus was found to occur to R(-)-DOM, S(+)-DOM, (+/-)-2,5-dimethoxyphenylisopropylamine (2,5-DMA), R(-)-2,-5-DMA, and the 2-demethyl derivative of (+/-)-DOM. The 3-methyl positional isomer of (+/-)-DOM was found to produce only 34% DOM-appropriate responding at the highest dose tested while administration of S(+)-2,5-DMA and the 5-demethyl derivative of (+/-)-DOM resulted in disruption of behavior.