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Discriminative stimulus properties of DOM and several molecular modifications.

Richard A Glennon, R Young, John A. Rosecrans

Pharmacology, Biochemistry, and Behavior April 1982 DOI: 10.1016/0091-3057(82)90413-0 (opens in new tab)

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AI-extracted from the abstract
Characteristics Observational study Peer reviewed
Population Rats trained to discriminate racemic DOM from saline
Interventions racemic 2 R(-)-DOM S(+)-DOM (+/-)-2 5-dimethoxyphenylisopropylamine (2 5-DMA) R(-)-2 5-DMA 2-demethyl derivative of (+/-)-DOM 3-methyl positional isomer of (+/-)-DOM S(+)-2 5-demethyl derivative of (+/-)-DOM
Dose 1.0 mg/kg for (+/-)-DOM training dose; other doses not specified
Key findings The discriminative stimulus effects of racemic DOM generalized to its R(-) and S(+) isomers, to 2,5-DMA and R(-)-2,5-DMA, and to the 2-demethyl derivative of DOM. The 3-methyl isomer produced only 34% DOM-appropriate responding at the highest dose tested, and S(+)-2,5-DMA and the 5-demethyl derivative disrupted behavior.

Abstract

Rats trained to discriminate racemic 2,5-dimethoxy-4-methylphenylisopropylamine, (+/-)-DOM (1.0 mg/kg), from saline in a two-lever drug discrimination task were challenged with the optimal isomers of DOM as well as with several related agents which represent minor molecular modifications of the DOM structure. Generalization of the (+/-)-DOM stimulus was found to occur to R(-)-DOM, S(+)-DOM, (+/-)-2,5-dimethoxyphenylisopropylamine (2,5-DMA), R(-)-2,-5-DMA, and the 2-demethyl derivative of (+/-)-DOM. The 3-methyl positional isomer of (+/-)-DOM was found to produce only 34% DOM-appropriate responding at the highest dose tested while administration of S(+)-2,5-DMA and the 5-demethyl derivative of (+/-)-DOM resulted in disruption of behavior.

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