Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A.
Thomas A Munro, Mark A Rizzacasa
Journal of Natural Products May 2003 DOI: 10.1021/np0205699 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Phytochemical isolation and structure-elucidation study Peer reviewed |
|---|---|
| Population | Leaves of Salvia divinorum |
| Topics | Salvia divinorum |
| Key points | Three new neoclerodane diterpenoids, salvinorins D-F, were isolated from Salvia divinorum leaves and their structures elucidated by chemical and spectroscopic methods, particularly 1D and 2D NMR. A simplified activated-carbon chromatography isolation method also gave improved yields of salvinorin A and salvinorin C. |
Abstract
Three new neoclerodane diterpenoids, salvinorins D-F (4-6), have been isolated from the leaves of Salvia divinorum. The structures were elucidated by chemical and spectroscopic methods, particularly 1D and 2D NMR. A simplified isolation method using chromatography on activated carbon also gave improved yields of the controlled substance salvinorin A (1) and of salvinorin C (3).
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- Psychopharmacology of the hallucinogenic sage Salvia divinorum. Life Sciences December 22, 2005
- Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A. Pharmacological Reviews June 1, 2011
- Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans. Neuroimage July 1, 2008
- Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery. Pharmacology & Therapeutics May 1, 2004
- Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors. British Journal of Pharmacology November 1, 2008
and 40 more in the library
Cites 4
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- Salvinorin C, a new neoclerodane diterpene from a bioactive fraction of the hallucinogenic Mexican mint Salvia divinorum. Organic Letters November 29, 2001
- Antidepressant Effects of the Herb Salvia Divinorum: A Case Report Journal of Clinical Psychopharmacology December 1, 2001
- Salvia divinorum and salvinorin A: new pharmacologic findings. Journal of Ethnopharmacology June 1, 1994