Antidepressant Effects of the Herb Salvia Divinorum: A Case Report
Journal of Clinical Psychopharmacology December 1, 2001 DOI: 10.1097/00004714-200112000-00025 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 26-year-old woman with history of depression |
| Interventions | Sertraline Cognitive-behavioural therapy |
| Dose | 50 mg daily |
| Duration | 3 months of sertraline, 6 months of cognitive-behavioural therapy |
| Topics | Salvia divinorum |
| Keywords | Antidepressant Traditional medicine Salvia Medicinal herbs |
| Citations | 69 |
| Key findings | Neither sertraline nor cognitive-behavioural therapy produced significant or sustained remission of depressive symptoms in this patient. |
Abstract
Ms. G is a 26-year-old woman with a history of depression that has shown no significant periods of remission since adolescence and has been predominated by feelings of worthlessness, lack of interest in social activities, an absence of occupational satisfaction, and inability to find purpose and meaning in her life. After first seeking treatment for her depression 5 years ago Ms. G was prescribed sertraline, 50 mg daily, which she self-discontinued after 3 months, reporting no significant benefits. Ms. G then underwent a course of cognitive-behavioural therapy for about 6 months, with some improvement but no definitive resolution of her symptoms. Hamilton Depression Rating Scale (HAM-D 1 ) scores during the 6-month period of cognitive-behavioural therapy were consistently in the moderately depressed range (i.e. 19-21).
Comparable studies
Other case reports and case series on salvia divinorum, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Salvia divinorum: an hallucinogenic mint which might become a new recreational drug in Switzerland. Salvia divinorum specimens seized in Switzerland | 2000 | Case study | |
| Chemogenomics knowledgebase and systems pharmacology for hallucinogen target identification-Salvinorin A as a case study. | 2016 | Database construction with computational prediction and case study | |
| A Report of Nausea and Vomiting with Discontinuation of Chronic Use of Salvia divinorum 51-year-old Caucasian woman | 2015 | Case study | n = 1 |
| Prolonged hallucinations and dissociative self mutilation following use ofSalvia divinorumin a bipolar adolescent girl A 17-year-old girl with bipolar disorder | 2010 | Case study | n = 1 |
| Case series: Salvia divinorum as a potential addictive hallucinogen. Patients presenting with an enduring and pervasive pattern of salvia use | 2018 | Case study | n = 2 |
Citations in the library
Cited by 41
- Here today, gone tomorrow…and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines. Journal of Medical Toxicology March 1, 2012
- Opioid receptors and legal highs:Salvia divinorumand Kratom Clinical Toxicology 2008
- Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. Journal of Pharmacology and Experimental Therapeutics March 1, 2004
- Potential anxiolytic‐ and antidepressant‐like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents British Journal of Pharmacology May 5, 2009
- Dose-related effects of salvinorin A in humans: dissociative, hallucinogenic, and memory effects. Psychopharmacology March 1, 2013
and 36 more in the library
Cites 5
- Divinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint, Salvia divinorum The Journal of Organic Chemistry November 1, 1984
- Ethnopharmacology of ska María Pastora (Salvia divinorum, Epling and Játiva-M.). Journal of Ethnopharmacology May 1, 1983
- Hallucinogenic Drugs in Psychiatric Research and Treatment Perspectives and Prospects The Journal of Nervous and Mental Disease March 1, 1995
- Psychedelic and Entactogenic Drugs in the Treatment of Depression Journal of Psychoactive Drugs 1994
- Salvia divinorum and salvinorin A: new pharmacologic findings. Journal of Ethnopharmacology June 1, 1994