Neo-clerodane diterpenes from the hallucinogenic sage Salvia divinorum.
Osamu Shirota, Kumi Nagamatsu, Setsuko Sekita
Journal of Natural Products December 1, 2006 DOI: 10.1021/np060456f (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Phytochemical study Peer reviewed |
|---|---|
| Population | Salvia divinorum plant material |
| Topics | Salvia divinorum |
| Keywords | Salvia divinorum chemistry Salvia divinorum compounds Salvia divinorum phytochemistry Salvia divinorum constituents Neo-clerodane diterpenes Salvidivins Salvinorins Divinatorin Natural product discovery Compound identification Chemical characterization Novel compounds Phytochemical research Plant chemistry |
| Citations | 68 |
| Key points | Seven new neo-clerodane diterpenes were isolated and structurally characterized from Salvia divinorum. |
Abstract
Seven new neo-clerodane diterpenes, salvidivins A (2), B, (3), C (4), and D (5), salvinorins H (6) and I (7), and divinatorin [corrected] F (8), along with eight known neo-clerodane diterpenes, salvinorins A (1)-F, divinatorins A and B, and seven other constituents, were isolated from the hallucinogenic sage Salvia divinorum. The structures of 1-7 were elucidated on the basis of 2D NMR spectroscopic studies.
Citations in the library
Cited by 18
- Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A. Pharmacological Reviews June 1, 2011
- Total synthesis of the hallucinogenic neoclerodane diterpenoid salvinorin A. Organic Letters April 3, 2008
- From local to global-fifty years of research on Salvia divinorum. Journal of Ethnopharmacology February 3, 2014
- A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics. Phytochemistry May 1, 2017
- Salvia divinorum use and phenomenology: results from an online survey. Journal of Psychopharmacology November 1, 2011
and 13 more in the library
Cites 13
- Divinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint, Salvia divinorum The Journal of Organic Chemistry November 1, 1984
- Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor. TIPS - Trends in Pharmacological Sciences March 1, 2003
- Salvinorin C, a new neoclerodane diterpene from a bioactive fraction of the hallucinogenic Mexican mint Salvia divinorum. Organic Letters November 29, 2001
- Salvia divinorum: an hallucinogenic mint which might become a new recreational drug in Switzerland. Forensic Science International August 14, 2000
- Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18). Bioorganic & Medicinal Chemistry Letters September 1, 2006
and 8 more in the library