Salvia divinorum and salvinorin A: new pharmacologic findings.
D J Siebert
Journal of Ethnopharmacology June 1, 1994 DOI: 10.1016/0378-8741(94)90116-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Intervention | Salvinorin A |
| Dose | 200-500 micrograms |
| Topics | Salvia divinorum |
| Keywords | Digestive system Mouth mucosa Humans Plants, medicinal Diterpenes, clerodane Growth substances Ion channels Receptors, cell surface Receptors, neurotransmitter Psychotropic drugs Plant extracts Monoamine oxidase inhibitors Chromatography, thin layer Magnetic resonance spectroscopy Administration, inhalation Administration, oral Absorption Abietanes |
| Key points | Salvinorin A, the active diterpene in Salvia divinorum, produces effects subjectively identical to the whole herb at doses of 200-500 micrograms. Because the gastrointestinal system deactivates it, traditional chewing of fresh leaves or drinking crushed-leaf juice relies on absorption through the oral mucosa before swallowing to maintain activity. |
Abstract
The diterpene salvinorin A from Salvia divinorum (Epling and Jativa-M), in doses of 200-500 micrograms produces effects which are subjectively identical to those experienced when the whole herb is ingested. Salvinorin A is effectively deactivated by the gastrointestinal system, so alternative routes of absorption must be used to maintain its activity. Traditionally the herb is consumed either by chewing the fresh leaves or by drinking the juices of freshly crushed leaves. The effects of the herb when consumed this way depend on absorption of salvinorin A through the oral mucosa before the herb is swallowed.
Citations in the library
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- Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proceedings of the National Academy of Sciences September 3, 2002
- Here today, gone tomorrow…and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines. Journal of Medical Toxicology March 1, 2012
- Opioid receptors and legal highs:Salvia divinorumand Kratom Clinical Toxicology 2008
- Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. Journal of Pharmacology and Experimental Therapeutics March 1, 2004
- Hallucinogens and dissociative agents naturally growing in the United States. Pharmacology & Therapeutics May 1, 2004
and 150 more in the library
Cites 3
- Salvinorin, a new trans-neoclerodane diterpene from Salvia divinorum(Labiatae) Journal of the Chemical Society Perkin Transactions 1 1982
- Divinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint, Salvia divinorum The Journal of Organic Chemistry November 1, 1984
- Ethnopharmacology of ska María Pastora (Salvia divinorum, Epling and Játiva-M.). Journal of Ethnopharmacology May 1, 1983