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Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder

Francisco Moreno, Christopher B. Wiegand, E. Keolani Taitano, Pedro L. Delgado

The Journal of Clinical Psychiatry November 15, 2006 DOI: 10.4088/jcp.v67n1110 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Controlled clinical trial Peer reviewed
Population Subjects with obsessive-compulsive disorder (OCD)
Intervention Psilocybin
Topics Anxiety Psilocybin
Keywords Tolerability Hallucinogen Adverse effect Obsessive compulsive Visual analogue scale Anesthesia Obsessive-compulsive spectrum disorders
Citations 786
Key findings Psilocybin was safely used in subjects with OCD and was associated with acute reductions in core OCD symptoms in several subjects.

Abstract

In a controlled clinical environment, psilocybin was safely used in subjects with OCD and was associated with acute reductions in core OCD symptoms in several subjects.

In the evidence

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Comparable studies

Other non-randomized and open-label trials on psilocybin for anxiety, most cited first.

Study Year Design Participants
Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression Patients with treatment-resistant depression 2018 Clinical trial n = 20
Emotions and brain function are altered up to one month after a single high dose of psilocybin. Healthy volunteers (7 female, 5 male) 2020 Open-label pilot study n = 12
Psilocybin-assisted group therapy for demoralized older long-term AIDS survivor men: An open-label safety and feasibility pilot study Older long-term AIDS survivor (OLTAS) self-identified gay men with moderate-to-severe... 2020 Open-label study
Psilocybin-Assisted Group Therapy and Attachment: Observed Reduction in Attachment Anxiety and Influences of Attachment Insecurity on the Psilocybin Experience Male long-term AIDS survivors with moderate-severe demoralization 2020 Open-label trial n = 18
Group format psychedelic-assisted therapy interventions: Observations and impressions from the HOPE trial Patients with a DSM-5 depressive disorder associated with a cancer diagnosis 2023 Open-label feasibility and safety pilot study

Citations in the library

Cited by 606

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Cites 11

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